{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:53:18Z","timestamp":1790848398950,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T00:00:00Z","timestamp":1682208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Alveolar ridge preservation (ARP) is a well\u2010defined treatment performed to reduce bone dimensional changes occurring during the healing of post\u2010extraction sockets to allow for adequate implant placement. Leukocyte and platelet\u2010rich fibrin (L\u2010PRF) has been showing to potentially promote bone and tissue regeneration during wound healing. Therefore, the aim of this study is to evaluate its efficacy for ARP when applied to fresh extraction sockets, in comparison with spontaneous healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Twenty\u2010seven patients with hopeless non\u2010molar teeth were treated. After randomization, fresh extraction sockets were either filled with L\u2010PRF or allowed to heal spontaneously. CBCTs and intraoral scans were obtained immediately after extraction and at 4\u2009months. Through superimposition of the obtained images, changes in the horizontal ridge width, height, buccal volume, and ridge contour changes were measured, as well as patient\u2010reported outcome measures (PROM's).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The ridge dimensions changed similarly in both groups. Although less reduction occurred in the test group at 1\u2009mm from the bone crest, differences were not statistically significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Application of L\u2010PRF did not prevent reductions of ridge contours, neither in the linear vertical aspect nor in volumetric changes. There were no differences between groups in the need for bone regeneration when placing implants. Patients in both groups reported similar outcomes in terms of bleeding, pain, inflammation, and function at 1 and 4\u2009weeks postoperatively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Alveolar preservation with L\u2010PRF neither minimized bone resorption occurring after tooth extraction in non\u2010molar sites nor reduced the need for bone regeneration when placing implants. Furthermore, its use did not improve PROM's.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cid.13208","type":"journal-article","created":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T21:59:47Z","timestamp":1682287187000},"page":"592-604","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Efficacy of the application of leukocyte and platelet\u2010rich fibrin (\n                    <scp>L\u2010PRF<\/scp>\n                    ) on alveolar ridge preservation. A randomized controlled clinical trial"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1338-0079","authenticated-orcid":false,"given":"Carolina Encalada","family":"Abad","sequence":"first","affiliation":[{"name":"Postgraduate program in Periodontology, Faculty of Odontology Complutense University of Madrid (UCM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3698-4772","authenticated-orcid":false,"given":"Ignacio","family":"Sanz\u2010Sanchez","sequence":"additional","affiliation":[{"name":"Postgraduate program in Periodontology, Faculty of Odontology Complutense University of Madrid (UCM)  Madrid Spain"},{"name":"ETEP (Etiology and Therapy of Periodontal and Peri\u2010implant Diseases) Research Group Complutense University of Madrid (UCM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Serrano","sequence":"additional","affiliation":[{"name":"Postgraduate program in Periodontology, Faculty of Odontology Complutense University of Madrid (UCM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0859-3149","authenticated-orcid":false,"given":"Javier","family":"Sanz Esporrin","sequence":"additional","affiliation":[{"name":"Postgraduate program in Periodontology, Faculty of Odontology Complutense University of Madrid (UCM)  Madrid Spain"},{"name":"ETEP (Etiology and Therapy of Periodontal and Peri\u2010implant Diseases) Research Group Complutense University of Madrid (UCM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7037-1163","authenticated-orcid":false,"given":"Ignacio","family":"Sanz\u2010Martin","sequence":"additional","affiliation":[{"name":"Postgraduate program in Periodontology, Faculty of Odontology Complutense University of Madrid (UCM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6293-5755","authenticated-orcid":false,"given":"Mariano","family":"Sanz","sequence":"additional","affiliation":[{"name":"Postgraduate program in Periodontology, Faculty of Odontology Complutense University of Madrid (UCM)  Madrid Spain"},{"name":"ETEP (Etiology and Therapy of Periodontal and Peri\u2010implant Diseases) Research Group Complutense University of Madrid (UCM)  Madrid 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