{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T01:00:42Z","timestamp":1794099642475,"version":"4.8.0"},"reference-count":96,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Analysis of the 3\u2010dimensional implant position, the bone defect morphology, and the soft tissue situation guides the decision to preserve or to remove an implant with a severe peri\u2010implantitis lesion. The aim of this narrative review was to analyze and to comprehensively illustrate the treatment options focusing on peri\u2010implant bone regeneration in presence of severe peri\u2010implant bone loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A database search was performed independently by the two reviewers to identify case reports, case series, cohort, retrospective, and prospective studies about peri\u2010implant bone regeneration with a follow\u2010up of at least 6\u2009months. Of the 344 studies issued during the database analysis, 96 publications were selected by the authors for this review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Deproteinized bovine bone mineral remains the best documented material for defect regeneration in peri\u2010implantitis in combination with or without a barrier membrane. While studies using autogenous bone in peri\u2010implantitis therapy are rarely found, they do report favorable potential of vertical bone regeneration. Moreover, while membranes are an inherent part of the guided bone regeneration, a 5\u2010year follow\u2010up study demonstrated clinical and radiographic improvements with and without a membrane. The administration of systemic antibiotics is frequently performed in clinical studies observing regenerative surgical peri\u2010implantitis therapy, but the analysis of the literature does not support a positive effect of this medication. Most studies for regenerative peri\u2010implantitis surgery recommend the removal of the prosthetic rehabilitation and the use a marginal incision with a full\u2010thickness access flap elevation. This allows for a good overview for regenerative procedures with a certain risk of wound dehiscences and incomplete regeneration. An alternative approach referring to the poncho technique may reduce the risk of dehiscence. The effectiveness of implant surface decontamination might have an impact on peri\u2010implant bone regeneration without any clinical superiority of a certain technique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The available literature reveals that the success of peri\u2010implantitis therapy is limited to the reduction of bleeding on probing, the improvement of the peri\u2010implant probing depth and a small amount of vertical defect fill. On this basis, no specific recommendations for bone regeneration in surgical peri\u2010implantitis therapy can be made. Innovative approaches for flap design, surface decontamination, bone defect grafting material, and soft tissue augmentation should be followed closely to find advanced techniques for favorable peri\u2010implant bone augmentation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cid.13209","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T01:50:47Z","timestamp":1684374647000},"page":"696-709","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Bone regeneration as treatment of peri\u2010implant disease: A narrative review"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2258-7909","authenticated-orcid":false,"given":"Robert","family":"Noelken","sequence":"first","affiliation":[{"name":"Private Practice for Oral Surgery, Lindau\/Lake Constance  Lindau Germany"},{"name":"Department of Oral and Maxillofacial Surgery University Medical 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