{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:46:12Z","timestamp":1766159172006,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["82170996"],"award-info":[{"award-number":["82170996"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare clinical and histological outcomes of sinus augmentation performed immediately or 3\u2009months after pseudocyst removal through a prospective randomized controlled study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In total, 33 sinus augmentation procedures were performed in 31 patients. Augmentation was performed either immediately after pseudocyst removal (one\u2010stage intervention) or after 3\u2009months (two\u2010stage intervention). Six months postoperatively, bone specimens were harvested, and histomorphometric analysis was performed as primary outcome. Data were recorded and evaluated for implant survival rates, marginal bone resorption, complication rate, and patient\u2010centered outcomes (visual analogue scale [VAS]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no baseline differences between groups or dropouts. Twelve biopsies obtained for histomorphometric analysis showed that delayed sinus augmentation, when compared to immediated led to a 1.1% increased mineralized bone ratio (95% confidence interval [CI]: \u221215.9 to 13.7). Graft leakage and acute sinusitis occurred in one patient in the one\u2010stage group, none in the two\u2010stage group. No pseudocyst recurrence was observed until the end of 1\u2010year follow\u2010up. Median VAS scores for overall acceptance were significantly increase of 1.4 (95% CI: 0.3\u20132.56) in immediate group. The degree of post\u2010operative discomfort was not significantly different, although an increase of VAS (0.52, 95% CI: \u22120.32 to 1.37) was observed in delay group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both procedures of sinus augmentation immediately and 3\u2009months after pseudocyst removal could obtain comparable histological outcomes and had low complication rates. Patients who underwent the one\u2010stage procedure had a short treatment course and high satisfaction rates, but this procedure is technically challenging to perform.<\/jats:p><jats:p>This clinical trial was not registered prior to participant recruitment and randomization. The clinical trial registration number is ChiCTR2200063121. The hyperlink is as follows: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.chictr.org.cn\/showproj.html?proj=172755\">https:\/\/www.chictr.org.cn\/showproj.html?proj=172755<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.13225","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T04:06:11Z","timestamp":1684814771000},"page":"967-973","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Immediately or delayed sinus augmentation after pseudocyst removal: A randomized trial"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9244-5813","authenticated-orcid":false,"given":"Huajie","family":"Yu","sequence":"first","affiliation":[{"name":"4th Division Peking University School and Hospital of Stomatology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiman","family":"Tang","sequence":"additional","affiliation":[{"name":"4th Division Peking University School and Hospital of Stomatology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danqing","family":"He","sequence":"additional","affiliation":[{"name":"Orthodontic Department Peking University School and Hospital of Stomatology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3451-0191","authenticated-orcid":false,"given":"Lixin","family":"Qiu","sequence":"additional","affiliation":[{"name":"4th Division Peking University School and Hospital of Stomatology  Beijing 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assessment in the integrated management of candidate for (maxillary) sinus lift","volume":"28","author":"Pignataro L","year":"2008","journal-title":"Acta Otorhinolaryngol Ital"},{"issue":"5","key":"e_1_2_10_13_1","first-page":"1205","article-title":"Clinical evaluation of lateral and osteotome techniques for sinus floor elevation in the presence of an antral pseudocyst","volume":"27","author":"Kara MI","year":"2012","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12708"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12505"},{"issue":"2","key":"e_1_2_10_16_1","first-page":"199","article-title":"Histomorphometric analysis of natural bone mineral for maxillary sinus augmentation","volume":"19","author":"John HD","year":"2004","journal-title":"Int J Oral Maxillofac Implants"},{"issue":"5","key":"e_1_2_10_17_1","first-page":"1230","article-title":"Influence of lateral window dimensions on vital bone formation following maxillary sinus augmentation","volume":"27","author":"Avila\u2010Ortiz G","year":"2012","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21040"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1079\u20102104(00)70090\u20104"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0278\u20102391(97)90063\u2010x"}],"container-title":["Clinical Implant Dentistry and Related 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