{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:46:13Z","timestamp":1790815573428,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,7,16]],"date-time":"2023-07-16T00:00:00Z","timestamp":1689465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The preservation and reconstruction of alveolar ridge volume in extraction sockets of molars affected by severe periodontitis is a critical challenge that requires clinical attention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This randomized controlled clinical trial was designed to evaluate the efficiency of autogenous partially demineralized dentin matrix (APDDM) for alveolar ridge preservation (ARP) in severely periodontally compromised sockets compared to spontaneous healing (SH) on radiographic and histomorphometric outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Thirty\u2010two patients with 32 periodontally compromised molars were randomized into either the test group, which received ARP using APDDM covered with a collagen sponge, or the control group, which underwent SH. Linear and volumetric changes were assessed using superimposed cone\u2010beam computed tomography (CBCT) acquired pre\u2010extraction and after a 4\u2010month healing time. Histomorphometric evaluation was performed on trephine cores harvested during implant placement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All sites healed uneventfully. The ridge width at 1\u2009mm apical to the bone crest increased by 5.03, 4.50, and 5.20\u2009mm in the mesial, middle, distal area in the APDDM group, while decreasing by \u22121.98, \u22122.19, and \u22121.98\u2009mm in the SH group, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The height increase of the central bone was significantly higher in the APDDM group than in the SH group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The height decrease of the buccal (mesial, middle, distal) bone plate was lower in the APDDM group than in the SH group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). After a 4\u2010month healing time, bone volume increased by 37.07% in the APDDM group and by only 2.33% in the SH group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Histomorphometric analysis revealed that APDDM particles were surrounded by newly formed bone, with partially absorbed residual APDDM materials observed. New bone, APDDM remnants, and connective tissue occupied 39.67\u2009\u00b1\u20098.28%, 23.66\u2009\u00b1\u20099.22%, and 36.67\u2009\u00b1\u200917.05% of the areas in the APDDM group, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ARP using APDDM was effective, resulting in a significant increase in both linear and volumetric changes in severely periodontally compromised extraction sockets compared to SH. These findings suggest that APDDM may serve as a promising new clinical option for the reconstruction of alveolar ridge dimensions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.13247","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T04:41:03Z","timestamp":1689568863000},"page":"1019-1032","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Alveolar ridge preservation in sockets with severe periodontal destruction using autogenous partially demineralized dentin matrix: A randomized controlled clinical trial"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1308-4827","authenticated-orcid":false,"given":"Fan","family":"Yang","sequence":"first","affiliation":[{"name":"Center for Plastic &amp; Reconstructive Surgery, Department of Stomatology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital) Hangzhou Medical College  Hangzhou 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