{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:13:32Z","timestamp":1787613212425,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This preclinical model study aims to evaluate the performance and safety of a novel hydroxyapatite biomaterial (Wishbone Hydroxyapatite, WHA) on guided bone regeneration compared to a commercially available deproteinized bovine bone mineral (Bio\u2010Oss, BO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Twenty\u2010four beagle dogs were allocated to three timepoint cohorts (4, 12, and 26\u2009weeks) of eight animals each. In all animals, four critical\u2010sized, independent wall mandibular defects were created (32 defects\/cohort). Each animal received all four treatments, allocated randomly to separated defects: WHA\u2009+\u2009collagen membrane (M), BO\u2009+\u2009M, no treatment (Sham, Sh), and Sh\u2009+\u2009M. At each timepoint, the specimens were harvested for histologic and histomorphometric analyses to determine the newly formed bone and osteoconductivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 4\u2009weeks, bone regeneration was significantly higher for WHA\u2009+\u2009M (46.8%) when compared to BO\u2009+\u2009M (21.4%), Sh (15.1%), and Sh\u2009+\u2009M (23.1%) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05); at 12 and 26\u2009weeks, regeneration was similar for WHA and BO. Bone\u2010to\u2010material contact increased over time similarly for WHA\u2009+\u2009M and BO\u2009+\u2009M. From a safety point of view, inflammation attributed to WHA\u2009+\u2009M or BO\u2009+\u2009M was minimal; necrosis or fatty infiltrate was absent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>WHA\u2009+\u2009M resulted in higher bone regeneration rate than BO\u2009+\u2009M at 4\u2009weeks. Both BO\u2009+\u2009M and WHA\u2009+\u2009M were more efficient than both Sh groups at all timepoints. Safety and biocompatibility of WHA was favorable and comparable to that of BO.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.13260","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T09:10:06Z","timestamp":1696410606000},"page":"183-196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Biological performance of a novel bovine hydroxyapatite in a guided bone regeneration model: A preclinical study in a mandibular defect in dogs"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9527-7616","authenticated-orcid":false,"given":"Bruno","family":"De Carvalho","sequence":"first","affiliation":[{"name":"Department of Periodontology, Oro\u2010Dental and Implant Surgery Dental Biomaterial Research Unit  Li\u00e8ge 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