{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T03:36:33Z","timestamp":1773804993686,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate patient safety, implants survival and implant stability of the bisphosphonate (zoledronate) as a coating on dental implants in patients requiring oral rehabilitation in the posterior maxilla.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In this multicenter, double\u2010blind, randomized controlled study, 62 patients were randomized to receive either zoledronate\u2010coated or uncoated control implants in the premolar or molar area of the maxilla, using a one stage\u2010protocol. Due to dropouts and exclusion 49 patients completed the study. The implants were examined by resonance frequency analysis (RFA) using an implant stability quotient (ISQ) scale at the time of insertion, and at 8\u2009weeks, and after 12\u2009weeks prior to prosthetic restoration. Radiographs were taken prior to surgery, directly after insertion, and during the follow\u2010up at 12\u2009weeks, 6\u2009months, and 1\u2009year to analyze changes in marginal bone levels (MBL). Finally, all complications and adverse effects (AE) were observed and recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 62 included patients, 49 patients completed the study. No AE were reported by patients receiving zoledronate\u2010coated implants. There was no statistically significant difference between the zoledronate\u2010coated or uncoated implant groups when comparing ISQ levels at insertion and after 12\u2009weeks of healing, the mean of the ISQ values demonstrated a change of 4.64 (95% confidence interval: 15.46; 5.79, <jats:italic>p<\/jats:italic>\u2009=\u20090.43) between the two groups. At 8\u2010 and 12\u2010weeks, ISQ values remained stable (range 62\u201370). Radiographic analysis showed no statistically significant difference in MBL between the two implant groups after 1\u2009year of loading neither at the mesial side (<jats:italic>p<\/jats:italic>\u2009=\u20090.99) or the distal side (<jats:italic>p<\/jats:italic>\u2009=\u20090.97). MBL for coated implants were 0.57\u2009mm at the mesial side and 0.46\u2009mm at the distal side. For the uncoated implants, MBL was 0.48\u2009mm at the mesial side and 0.47\u2009mm at the distal side.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The zoledronate\u2010coated dental implants are safe to use in a one\u2010stage surgery protocol in patients requiring oral rehabilitation in the posterior maxilla, after 1\u2009year of loading. There were no statically significant changes in implant stability and marginal bone levels measured by intraoral radiographs in comparison to uncoated control implants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.13288","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T05:47:50Z","timestamp":1697608070000},"page":"78-87","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A randomized, multicenter, double\u2010blinded parallel study to evaluate the safety and performance of zoledronate\u2010coated versus uncoated dental implants in partially edentulous patients"],"prefix":"10.1111","volume":"26","author":[{"given":"Reza A.","family":"Mokhtari","sequence":"first","affiliation":[{"name":"Department of ENT &amp; Oral and Maxillofacial Surgery Nu\u2010Sjukv\u00e5rden  Trollh\u00e4ttan Sweden"},{"name":"Department of Biomaterials, Institute of Clinical Sciences, The Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgan","family":"Olsson","sequence":"additional","affiliation":[{"name":"Private Practice of Dental and Oral Surgery  Dingle Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per\u2010Olov","family":"\u00d6stman","sequence":"additional","affiliation":[{"name":"Private Practice of Dental and Oral Surgery  Falun Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7131-5577","authenticated-orcid":false,"given":"Christer","family":"Dahlin","sequence":"additional","affiliation":[{"name":"Department of ENT &amp; 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