{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:11:28Z","timestamp":1789495888558,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Alveolar ridge preservation (ARP) is a technique that aims to maintain bone volume and minimize resorption after tooth extraction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to compare the effectiveness of injectable platelet\u2010rich fibrin (I\u2010PRF) versus hyaluronic acid (HA) in combination with xenografts for ARP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This randomized controlled trial included 36 patients (20 females and 16 males) who required implant placement in the upper arch. The patients were randomly allocated to one of three groups (<jats:italic>n<\/jats:italic>\u2009=\u200912 each): I\u2010PRF with xenografts, HA with xenografts, or xenografts alone. All patients underwent ARP, and the extraction sockets were sealed with a free gingival graft harvested from the palate, a total of 36 implants were inserted. Cone\u2010beam CT scans were performed before and 4\u2009months postoperatively to measure radiographic bone gain as the primary outcome. Clinical parameters, including soft tissue thickness and clinical bone width, were evaluated preoperatively, and at 4\u2009months and 1\u2009year postoperatively. Additionally, histological assessment of core bone biopsies was performed 4\u2009months postoperatively using histomorphometric analysis to determine the percentages of newly formed bone, mature bone, and residual grafts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Regarding the radiographic bone gain 4\u2009months postoperative the HA group exhibited the highest value (9.78\u2009\u00b1\u20090.87), which was significantly greater than the values observed in the I\u2010PRF and control groups (8.60\u2009\u00b1\u20091.27 and 7.99\u2009\u00b1\u20090.89, respectively) (one\u2010way ANOVA, <jats:italic>p<\/jats:italic>\u2009=\u20090.007). Crestal bone loss was significantly higher in the control group (\u22120.98\u2009\u00b1\u20090.18) than in the I\u2010PRF group (\u22120.53\u2009\u00b1\u20090.11) and HA group (\u22120.33\u2009\u00b1\u20090.15) groups (one\u2010way ANOVA, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In the histomorphometric analysis, the mean area fraction of newly formed bone trabeculae was significantly higher in the HA group (56.66\u2009\u00b1\u20097.35) than in the I\u2010PRF group (28.74\u2009\u00b1\u20095.15) and the control group (24.05\u2009\u00b1\u20093.64) (repeated measures ANOVA, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Additionally, the mean area fraction of residual graft material was higher in the I\u2010PRF group (6.76 \u00b1 2.59), followed by the control group (2.71\u2009\u00b1\u20091.24), while the HA group had the lowest value (2.63\u2009\u00b1\u20091.27) (Repeated measures ANOVA, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of HA with xenografts yielded better radiographic and histological outcomes in terms of new bone formation and degree of bone maturation than the I\u2010PRF and control groups. Furthermore, I\u2010PRF improved soft tissue thickness.<\/jats:p><jats:p>Please note that clinical trial registration was not completed prior to participant recruitment and randomization. The registration link for this trial is <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05781529\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05781529<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.13289","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T11:16:25Z","timestamp":1698750985000},"page":"88-102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Injectable platelet rich fibrin versus hyaluronic acid with bovine derived xenograft for alveolar ridge preservation. A randomized controlled clinical trial with histomorphometric analysis"],"prefix":"10.1111","volume":"26","author":[{"given":"Gehad","family":"Abaza","sequence":"first","affiliation":[{"name":"Master Periodontology, Faculty of Dentistry Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala Kamal","family":"Abdel Gaber","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Periodontology and Diagnosis, Faculty of Dentistry Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0271-3656","authenticated-orcid":false,"given":"Nermeen Sami","family":"Afifi","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Faculty of Dentistry Ain Shams University and Misr International University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0254-0890","authenticated-orcid":false,"given":"Doaa","family":"Adel\u2010Khattab","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Periodontology and Diagnosis, Faculty of Dentistry Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13770-021-00428-y"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02375.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12364"},{"issue":"4","key":"e_1_2_11_5_1","first-page":"313","article-title":"Bone healing and soft tissue contour changes following single\u2010tooth extraction: a clinical and radiographic 12\u2010month prospective study","volume":"23","author":"Schropp L","year":"2003","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00726.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0b013e3181813406"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.01922.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2000040002"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.150500"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2010.01301.x"},{"issue":"2","key":"e_1_2_11_12_1","first-page":"63","article-title":"Alveolar bone regeneration in post\u2010extraction socket: a review of materials to postpone dental implant","volume":"21","author":"Porrini R","year":"2011","journal-title":"Biomed Mater Eng"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2011.554814"},{"key":"e_1_2_11_14_1","first-page":"55","article-title":"Une opportunit\u00e9 en paro\u2010implantologie: le PRF","volume":"42","author":"Choukroun J","year":"2001","journal-title":"Implant Dent"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1563\/aaid-joi-D-14-00138"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-017-5992-6"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-017-2133-z"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2017.1401058"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma13102282"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.39.23853"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830230826"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb8030031"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0394632016652906"},{"issue":"2","key":"e_1_2_11_24_1","first-page":"99","article-title":"A simplified socket classification and repair technique","volume":"19","author":"Elian N","year":"2007","journal-title":"Pract Proced Aesthet Dent"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1949.02900410026007"},{"key":"e_1_2_11_26_1","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J","year":"1988"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03193146"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1967.38.6.610"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18020331"},{"key":"e_1_2_11_30_1","first-page":"11","article-title":"A modified sur\u2010gical\/prosthetic approach for optimal single implant supported crown. 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