{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T07:32:23Z","timestamp":1787643143774,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T00:00:00Z","timestamp":1705276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Oro\u2010control communication is one of the complications associated with dental extraction and oral surgeries. This case report presents a minimally invasive surgical approach for bone regeneration at the site of oro\u2010antral communication utilizing a prefabricated computer\u2010aided design and computer\u2010aided manufacturing (CAD\u2010CAM) allogenic bone block.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 20\u2010year\u2010old healthy female, nonsmoker, with a badly destructed upper right first molar was referred for dental implant placement after extraction. Cone beam computerized tomography images revealed the presence of a large bone defect associated with oro\u2010antral communication with the maxillary sinus and insufficient bone for dental implant placement. A prefabricated CAD\u2010CAM allogenic bone scaffold was fabricated. After surgical exposure, the scaffold was secured in place and covered with a non\u2010resorbable membrane. A dental implant was placed after 5\u2009months, and a trephining biopsy was processed for histological evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Closure of the oro\u2010antral communication was clinically observed. The average width of the alveolar bone was 12\u2009mm, and the average height was 11\u2009mm. Histological analysis at 5\u2010month intervals showed thin newly formed bone trabeculae encircling remnants of graft material surrounded by osteoid tissue. The newly formed bone percentages were 32\u2009\u00b1\u200918% and 28\u2009\u00b1\u200917% volume remained after the biodegradation of the scaffold. Specific immune\u2010histochemical staining by anti\u2010vascular epithelial growth factor expression index value was 32.06%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A prefabricated CAD\u2010CAM scaffold was successfully used to seal a large oro\u2010antral communication and regenerate sufficient bone to place a dental implant.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.13300","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T06:43:28Z","timestamp":1705387408000},"page":"258-265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prefabricated <scp>CAD\u2010CAM<\/scp> scaffolds for management of oro\u2010antral communication: A case report and histological analysis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4064-4981","authenticated-orcid":false,"given":"Mohamed H.","family":"Helal","sequence":"first","affiliation":[{"name":"Oral Medicine, Periodontology, Oral Diagnosis, and Radiology Department, Faculty of Dentistry Tanta University  Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5168-377X","authenticated-orcid":false,"given":"Ahmed N.","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Basic Medical and Dental Sciences Faculty of Dentistry, Zarqa University  Zarqa Jordan"},{"name":"Oral Pathology Department, Faculty of Dentistry Tanta University  Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5372-5222","authenticated-orcid":false,"given":"Sahar F.","family":"Ghoraba","sequence":"additional","affiliation":[{"name":"Oral Medicine, Periodontology, Oral Diagnosis, and Radiology Department, Faculty of Dentistry Tanta University  Tanta 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