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Chitosan\u2010based nanoparticles (NP) and a polyvinyl alcohol film (PVA). The size, \u03b6\u2010potential, stability, adhesive properties, and encapsulation profile of NP, as well as the release kinetics of drug delivery systems and their antimicrobial ability of PVA and PVANP films, were studied on Ti surfaces. The systems were loaded with doxycycline, vancomycin, and doxepin hydrochloride.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nanoparticles presented a \u03b6\u2010potential greater than 30\u2009mV for 45\u2009days and the efficiency drug encapsulation was 26.88%\u2009\u00b1\u20091.51% for doxycycline, 16.09%\u2009\u00b1\u200910.24% for vancomycin and 17.57%\u2009\u00b1\u200911.08% for doxepin. In addition, PVA films were loaded with 125\u2009\u03bcg\/mL of doxycycline, 125\u2009\u03bcg\/mL of vancomycin, and 100\u2009\u03bcg\/mL of doxepin. PVANP\u2010doxycycline achieved the antibacterial effect at 4\u2009h while PVA\u2010doxycycline maintained its effect at 24\u2009h.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.13305","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T05:39:27Z","timestamp":1709185167000},"page":"427-441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Novel Ti surface coated with <scp>PVA<\/scp> hydrogel and chitosan nanoparticles with antibacterial drug release: An experimental in vitro study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8638-6001","authenticated-orcid":false,"given":"Pablo Yael","family":"Carrazco \u00c1vila","sequence":"first","affiliation":[{"name":"Department of Stomatology, School of Dentistry, Campus de Cartuja s\/n University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Arias Moliz","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Dentistry University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4575-4098","authenticated-orcid":false,"given":"Juan Ignacio","family":"Rosales Leal","sequence":"additional","affiliation":[{"name":"Department of Stomatology, School of Dentistry, Campus de Cartuja s\/n University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Baca","sequence":"additional","affiliation":[{"name":"Department of Stomatology, School of Dentistry, Campus de Cartuja s\/n University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Rodr\u00edguez Valverde","sequence":"additional","affiliation":[{"name":"Department of applied Physics, School of Science University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Encarnaci\u00f3n","family":"Morales Hernandez","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, Campus de Cartuja s.n. 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