{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T20:18:42Z","timestamp":1778876322003,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of this study was to determine clinically and genetically the allergic effects of titanium and poly\u2010ether\u2010ether\u2010ketone (PEEK) implants following loading in rabbit tibias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>This study included 18 white New Zealand male rabbits (<jats:italic>n<\/jats:italic>\u2009=\u200918) divided evenly into three groups: control, titanium (Ti), and PEEK (P). Clinically, the allergenic effect of titanium and PEEK was investigated by detecting the effect on lymph nodes. Furthermore, RT\u2010PCR and ELISA were used to detect the expression of certain genes IL\u20106, TNF\u2010\u03b1, OPG, RANKL, and RUNX\u20102 through both types of implants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our findings demonstrated that titanium implants induced enlarged lymph nodes, which PEEK did not. Overall, RT\u2010PCR and ELISA techniques revealed that Ti implants had higher expression of the inflammatory genes IL\u20106 and TNF\u2010\u03b1. Ti had the highest expression in OPG findings, while PEEK had the lowest. RANKL expression was highest in the control group and lowest in the PEEK group. RUNX\u20102 is the highest for the control group and the lowest for the titanium group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although titanium implants elicited greater allergy responses than PEEK implants, titanium has the highest expression of bone formation genes and the lowest expression of bone resorption genes, making it preferable to PEEK.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.13323","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T13:24:30Z","timestamp":1712237070000},"page":"671-678","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Allergic reaction of poly\u2010ether\u2010ether\u2010ketone versus titanium implants: A posttest\u2010only control group design experimental study using a rabbit 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