{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:01:07Z","timestamp":1792080067958,"version":"4.4.0"},"reference-count":78,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Dental implants are widely employed as dependable replacements for lost teeth. However, it is crucial to establish, solely through prospective cohort studies, whether a history of periodontitis indeed constitutes a significant risk factor for implant failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic literature search was conducted in October 2022 in several electronic databases with subsequent manual updates. Only original prospective cohort studies evaluating the implant (loss) rate \u22651\u2009year after implant loading were included. Logarithmic risk ratio and weighted mean differences were calculated. Study results were summarized using random effects meta\u2010analyses evaluated by trial sequential analyses. The Newcastle\u2010Ottawa scale evaluated study bias and the GRADE approach assessed the certainty\/quality of the evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 14 publications reporting on 12 prospective cohort studies were included. Low evidence certainty\/quality evidence due to the absence of randomized clinical trials revealed significantly greater odds of failure in patients with a history of periodontitis at follow\u2010ups both after \u22645\u2009years (RR\u2009=\u20091.62; 95% CI: 1.71\u20132.37;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013) and &gt;5\u2009years (RR\u2009=\u20092.26; 95% CI: 1.12\u20134.53;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023). The incidence of peri\u2010implantitis (RR\u2009=\u20094.09; 95% CI: 1.93\u20138.58;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and the weighted mean (WM) of marginal bone loss (WM difference\u2009=\u20090.75\u2009mm; 95% CI: 0.18\u20131.31;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) were statistically significantly greater in the periodontally compromised group, whereas there was no significant difference between the two groups for peri\u2010implant probing depth.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A history of periodontitis can be considered a significant risk factor for incident implant failure, peri\u2010implantitis, and greater marginal bone loss.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cid.13330","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T02:50:02Z","timestamp":1715223002000},"page":"482-508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["History of periodontitis as a risk factor for implant failure and incidence of peri\u2010implantitis: A systematic review, meta\u2010analysis, and trial sequential analysis of prospective cohort studies"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2081-6651","authenticated-orcid":false,"given":"Matteo","family":"Serroni","sequence":"first","affiliation":[{"name":"Unit of Periodontics and Dental Hygiene, Department of Innovative Technologies in Medicine &amp; Dentistry University \u2018G. 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