{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T10:42:15Z","timestamp":1781260935056,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the histomorphometric and computerized microtomographic (Micro\u2010CT) analysis of the regenerated bone tissue from maxillary sinus augmentation surgery, with and without using the collagen membrane on the external osteotomy window.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twelve patients were selected for this prospective, controlled, and randomized study. The patients were submitted to bilateral maxillary sinus surgery in a split\u2010mouth design. On the test side, the maxillary sinus augmentation procedure included using Geistlich Bio\u2010Oss\u00ae and a Geistlich Bio\u2010Gide\u00ae collagen membrane covering the lateral osteotomy window. On the control side, only Geistlich Bio\u2010Oss\u00ae was used without the presence of the membrane. After 6\u2009months, the surgeries for implant installation were performed. In this surgical phase, specimens of the regenerated tissue were collected for histological and Micro\u2010CT analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the histomorphometric evaluation, the mean (\u00b1SD) percentages of newly formed bone were 43.9% (\u00b111.5) and 40.8% (\u00b18.9) in the test and control groups, respectively. The corresponding values of the Micro\u2010CT analysis were 36.6% (\u00b13.4) and 37.2% (\u00b14.7) in the test and control groups, respectively. There was no statistically significant difference between the test and control groups in the two methods. In addition, there was no statistically significant difference between the mean percentage of biomaterial remaining between the test and control groups. However, the mean percentage of newly formed bone was significantly higher and the mean percentage of remaining biomaterial was significantly lower in the histomorphometric analysis compared to the values obtained through microtomography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The additional use of collagen membranes in maxillary sinus surgery does not offer advantages in newly formed bone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.13331","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T09:18:46Z","timestamp":1718961526000},"page":"787-794","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Histomorphometric and microtomographic analysis of maxillary sinus augmentation surgeries with and without collagen membrane on the lateral window: A randomized clinical trial"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3935-3295","authenticated-orcid":false,"given":"Ramiro Beato","family":"Souza","sequence":"first","affiliation":[{"name":"Oral and Maxillofacial Surgeon of Pedro Ernesto University Hospital Rio de Janeiro State University  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haimon Diniz Lopes","family":"Alves","sequence":"additional","affiliation":[{"name":"Physics Department Rio de Janeiro State University  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano Santos","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Implantology Catholic University of Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Ramoa","family":"Pires","sequence":"additional","affiliation":[{"name":"Oral Pathology, Dental School, Rio de Janeiro State University, Brazil Rio de Janeiro State University  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4514-6906","authenticated-orcid":false,"suffix":"Jr","given":"Guaracilei Maciel","family":"Vidigal","sequence":"additional","affiliation":[{"name":"Department of Periodontology Rio de Janeiro State University  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Guimaraes","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Periodontology Rio de Janeiro State University  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"905","volume-title":"Contemporary Implant Dentistry","author":"Misch CE","year":"2008"},{"key":"e_1_2_9_3_1","first-page":"565","article-title":"Systematic review of survival rates for implants 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prospective study","volume":"20","author":"Tarnow DP","year":"2000","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_9_9_1","first-page":"551","article-title":"Sinus augmentation utilizing anorganic bovine bone (Bio\u2010Oss) with absorbable and nonabsorbable membranes placed over the lateral window: histomorphometric and clinical analyses","volume":"25","author":"Wallace SS","year":"2005","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.id.0000220120.54308.f3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02431.x"},{"key":"e_1_2_9_12_1","first-page":"199","article-title":"Histomorphometric analysis of natural bone mineral for maxillary sinus augmentation","volume":"19","author":"John HD","year":"2004","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_9_13_1","first-page":"1","article-title":"Maxillary sinus augmentation with a new 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P","year":"2000","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_9_20_1","first-page":"47","volume-title":"20\u2009Years of Guided Bone Regeneration in Implant Dentistry","author":"Buser D","year":"2009"},{"key":"e_1_2_9_21_1","first-page":"713","article-title":"Sinus floor elevation using a bovine bone mineral (Bio\u2010Oss) with or without the concomitant use of a bilayered collagen barrier (Bio\u2010Guide): a clinical report of immediate and delayed implant placement","volume":"16","author":"Tawil G","year":"2001","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02340.x"},{"key":"e_1_2_9_23_1","first-page":"73","article-title":"The effects of resorbable membrane on human maxillary sinus graft: a pilot study","volume":"24","author":"Choi KS","year":"2009","journal-title":"J Oral Maxillofac 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