{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:19:52Z","timestamp":1790018392660,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019921","name":"Geistlich Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to assess radiographic marginal bone changes 22 months post extraction, which is 1\u2009year after implant loading in alveolar ridge preservation (ARP) sites grafted with a combination of collagen\u2010embedded xenogenic bone substitute (DBBM\u2010C) and collagen matrix (CMX), comparing them with implants placed in naturally healed sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This randomized controlled clinical trial was conducted over 22\u2009months. Patients who needed a single tooth extraction and subsequent implant placement in nonmolar areas were enrolled. The test group received deproteinized bovine bone mineral with 10% collagen covered by a procaine collagen membrane, while the control group allowed spontaneous healing. Radiographic bone level changes were documented using periapical radiographs at implant placement and follow\u2010up visits (6, 10, and 22\u2009months postextraction). Early implant soft tissue exposure, clinical parameters, and patient\u2010reported outcomes were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two out of 28 participants completed a 22\u2010month follow\u2010up, 9 in the test group and 13 in the control group. At 10\u2010month postextraction follow\u2010up, the mean MBL was 1.01\u2009\u00b1\u20091.04\u2009mm in the treatment group and 0.81\u2009\u00b1\u20090.93\u2009mm in the control group (<jats:italic>p<\/jats:italic>\u2009=\u20090.804). At 22\u2009months, the mean MBL was 2.09\u2009\u00b1\u20091.03\u2009mm in the treatment group and 1.58\u2009\u00b1\u20090.73\u2009mm in the control group (<jats:italic>p<\/jats:italic>\u2009=\u20090.339). No statistically significant differences in probing depth (PD) and bleeding on probing (BOP) were found at the 22\u2009\u2010month follow\u2010up as well. Soft tissue mean recession was observed in the control group (0.36\u2009\u00b1\u20090.84\u2009mm), while no recession was found in the test group (<jats:italic>p<\/jats:italic>\u2009=\u20090.2). Early implant soft tissue exposure occurred in 33% of test group participants, while none was observed in the control group (<jats:italic>p<\/jats:italic>\u2009=\u20090.047).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>One year after implant loading, no significant differences in marginal bone resorption were found between implants placed in ARP\u2010treated and naturally healed sites. However, ARP\u2010treated sites exhibited early implant soft\u2010tissue exposure, suggesting a possible impairment in soft tissue healing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.13348","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T04:54:46Z","timestamp":1716958486000},"page":"742-749","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tissue changes around dental implants installed in alveolar ridge preservation sites: A 1\u2010year follow\u2010up randomized controlled clinical trial"],"prefix":"10.1111","volume":"26","author":[{"given":"Eran","family":"Gabay","sequence":"first","affiliation":[{"name":"Department of Periodontology and Implant dentistry Rambam health care campus  Haifa Israel"},{"name":"Rappaport Faculty of Medicine Technion institute of technology  Haifa 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