{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:13:49Z","timestamp":1790129629416,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["2022R1A2C2005537"],"award-info":[{"award-number":["2022R1A2C2005537"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Cutibacterium acnes<\/jats:italic> is a facultative anaerobic, gram\u2010positive rod, and a commensal bacterium of the body surface including oral cavity. A causal relationship between <jats:italic>C. acnes<\/jats:italic> and chronic granulomatous diseases, such as sarcoidosis and orthopedic implant\u2010associated infections, has been previously reported. Typically, <jats:italic>C. acnes<\/jats:italic> has been observed inside macrophages, allowing evasion of host immunity, and triggering a persistent inflammatory response. However, such findings have not been reported in peri\u2010implantitis lesions. In this case series, we collected inflamed tissues from extensive peri\u2010implantitis lesions of eight patients. Out of the eight samples, seven tested positive for the 16\u2009s rRNA gene of <jats:italic>C. acnes<\/jats:italic> by polymerase chain reaction, and six were positive by immunohistochemistry. Immunohistochemical staining revealed the presence of <jats:italic>C. acnes<\/jats:italic> in the cytoplasm of macrophages, suggesting a role in lesion formation. This finding may enhance our understanding of the pathophysiology of persistent peri\u2010implantitis lesions and provide implications for future therapy.<\/jats:p>","DOI":"10.1111\/cid.13367","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T21:54:10Z","timestamp":1723586050000},"page":"1126-1134","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Intracellular infection of <i>Cutibacterium acnes<\/i> in macrophages of extensive peri\u2010implantitis lesions: A clinical case series"],"prefix":"10.1111","volume":"26","author":[{"given":"Jin\u2010Young","family":"Park","sequence":"first","affiliation":[{"name":"Department of Periodontology, Research Institute for Periodontal Regeneration Yonsei University College of Dentistry  Seoul Republic of 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