{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:22:25Z","timestamp":1780546945285,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the efficacy of guided bone regeneration (GBR) for the treatment of peri\u2010implant dehiscence defects using a synthetic bone substitute (SBS) or a deproteinized bovine bone mineral (DBBM) as a bone substitute.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with expected dehiscence defects following implant placement were randomized to use either SBS or DBBM together with a bioabsorbable collagen membrane over dehiscenced implant surfaces aimed for GBR. The changes in the bone defect size were measured before the GBR procedure and 6\u2009months after implant placement at the re\u2010entry surgery. Secondary outcomes included peri\u2010implant health outcomes, implant cumulative survival rates, bone level changes, and patient\u2010reported outcomes (PROMs) at prosthesis delivery and 1\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 49 included patients, 24 were treated with SBS and 25 with DBBM. In the SBS group, the defect height (DH) at implant insertion was 5.1\u2009\u00b1\u20092.6\u2009mm and was reduced at re\u2010entry to 1.3\u2009\u00b1\u20092.0\u2009mm (74.5%). In the DBBM group, the respective changes in DH were 4.1\u2009\u00b1\u20091.7\u2009mm and 1.5\u2009\u00b1\u20091.9\u2009mm (63.4%). These differences were not statistically significant (<jats:italic>p<\/jats:italic>\u2009=\u20090.216). The complete defect resolution rate was also comparable in both groups without statistical difference (62.5% of patients (15\/24) vs. 44% of patients (11\/25)). Overall, the marginal bone levels remained stable during the 1\u2010year follow\u2010up in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The SBS is noninferior to DBBM for simultaneous GBR to implant placement at implant sites with buccal dehiscences in terms of defect resolution and evaluated secondary outcomes (KCT0008393 \u2212 this clinical trial was not registered before participant recruitment and randomization).<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.13386","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T05:29:54Z","timestamp":1725427794000},"page":"1233-1244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Guided bone regeneration at dehiscence comparing synthetic bone substitute versus bovine bone mineral: A multicenter, noninferiority, randomized trial"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6906-7209","authenticated-orcid":false,"given":"Jae\u2010Kook","family":"Cha","sequence":"first","affiliation":[{"name":"Department of Periodontology, Research Institute for Periodontal Regeneration Yonsei University College of Dentistry  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6371-4172","authenticated-orcid":false,"given":"Ui\u2010Won","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Research Institute for Periodontal Regeneration Yonsei University College of Dentistry  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Montero\u2010Solis","sequence":"additional","affiliation":[{"name":"ETEP (Etiology and Therapy of Periodontal and Peri\u2010Implant Diseases) Research Group University Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3698-4772","authenticated-orcid":false,"given":"Ignacio","family":"Sanz\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"ETEP (Etiology and Therapy of Periodontal and Peri\u2010Implant Diseases) Research Group University Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Sanz\u2010Alonso","sequence":"additional","affiliation":[{"name":"ETEP (Etiology and Therapy of Periodontal and Peri\u2010Implant Diseases) Research Group University Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12074"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13390"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13953"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12539"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12531"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12877"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.3329"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13078"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2015.03.005"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.01918.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13606"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2022.104323"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12802"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13726"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12039"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2019.10.011"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2003.00921.x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13050"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13209"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13515"},{"key":"e_1_2_11_22_1","first-page":"271","article-title":"Comparing membranes and bone substitutes in a one\u2010stage procedure for horizontal bone augmentation. 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