{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T03:40:56Z","timestamp":1792381256453,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T00:00:00Z","timestamp":1734220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T00:00:00Z","timestamp":1734220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the clinical efficacy of oral systemic antibiotic prophylaxis administered along with the surgical reconstructive peri\u2010implantitis treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 49 patients exhibiting 70 implants diagnosed with peri\u2010implantitis underwent a surgical reconstructive peri\u2010implantitis treatment. Of them, 27 patients (38 implants) received a single preoperative shot of antibiotics (2\u2009g amoxicillin; Pre\u2010op), 12 patients (19 implants) were prescribed with postoperative antibiotics for 3\u2009days (500\u2009mg amoxicillin, 3 x day, Post\u2010op), and the remaining 10 patients (13 implants) did not receive any systemic antibiotics (No\u2010Ab). Mean probing depth values (mean PDs; primary outcome), bleeding on probing (BOP), plaque (PI), suppuration (Sup), and deepest PDs values (max PD) were assessed prior to surgery (baseline), after 6 and 12\u2009months. To assess the differences in changes in the clinical parameters, and disease resolution (PD \u2264\u20095\u2009mm, \u2264\u20091 BOP site and no Sup) among the groups, logistic regression analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 12\u2009months, the mean PD reduction amounted to \u22121.74\u2009\u00b1\u20091.56\u2009mm, \u22121.91\u2009\u00b1\u20091.88\u2009mm, and \u22121.13\u2009\u00b1\u20091.05\u2009mm in the No\u2010Ab, Pre\u2010op, and Post\u2010op groups, respectively, with no significant difference detected among the groups. The BOP was reduced in 60%, 59.3%, and 83.3% of the patients after 12\u2009months in the No\u2010Ab, Pre\u2010op, and Post\u2010op groups, respectively, with no significant differences among them. The PI, Sup and max PD reductions were comparable among the groups. Disease resolution after 12\u2009months was established in 61.5%, 73.7%, and 89.5% of patients in the No\u2010Ab, Pre\u2010op, and Post\u2010op groups (No\u2010Ab vs. Pre\u2010op:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.10, No\u2010Ab vs. Post\u2010op:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.40, Pre\u2010op vs. Post\u2010op:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.84).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Systemic antibiotic prophylaxis did not improve the clinical outcomes of surgical reconstructive peri\u2010implantitis treatment.<\/jats:p>\n                  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