{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:54:55Z","timestamp":1787936095805,"version":"build-2784847793"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The purpose of this study was to verify the effect of our previously proposed mesiodistal distance for multiple posterior implants on preserving peri\u2010implant bone, and to provide a measurable criterion for predicting implant prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and two patients with dental implants placed in the posterior free\u2010end edentulous arches were recruited in this cross\u2010sectional study. Calibrated X\u2010rays (peri\u2010apical [PA] or bite\u2010wing x\u2010ray) were collected to measure the mesiodistal space as well as the corresponding bone resorption of implants after prosthesis placement. Implants were assigned to the test\/control group according to whether their mesiodistal distance following our proposed algorithm. After adjusting covariates, logistic multivariate regression analyses were performed to examine the relationship between inter\u2010implant distance and marginal bone loss (MBL) during each follow\u2010up interval. The effect of smoking habits was also analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Every observation period exhibited great significance between experimental and control group on peri\u2010implant bone level (<jats:italic>p<\/jats:italic>\u2009=\u20090.006, 0.005, 0.001, 0.025, 0.001, correspondingly) and the difference had a tendency to grow as time went by except 4\u2010year (MD\u2009=\u2009\u22120.19, \u22120.39, \u22120.43, \u22120.30, \u22121.26, correspondingly). While no significant difference was observed between smokers and nonsmokers in the same group (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The mesiodistal algorithm of 4\u20134.6\u2009mm (implant to adjacent canine tooth), 7\u20137.4\u2009mm, 8\u20138.5\u2009mm, and 9\u20139.5\u2009mm was proved to be effective for maintaining peri\u2010implant bone level. It was also observed in our study that the impact of inter\u2010implant distance outweighed that of smoking. This study provided clinicians predictable prognostic outcomes for implants and reference for deciding treatment plans.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.13442","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:58:40Z","timestamp":1737593920000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Implant Mesiodistal Distance on Peri\u2010Implant Bone Loss: A Cross\u2010Sectional Retrospective Study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0092-4276","authenticated-orcid":false,"given":"Wenwen","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Geriatric Dentistry Peking University School and Hospital of Stomatology  Beijing China"},{"name":"Department of Periodontics and Oral Medicine The University of Michigan School of Dentistry  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Geriatric Dentistry Peking University School and Hospital of Stomatology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine The University of Michigan School of Dentistry  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Li","sequence":"additional","affiliation":[{"name":"The Department of Nosocial Infection Management Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4238-1799","authenticated-orcid":false,"given":"Hom\u2010Lay","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine The University of Michigan School of Dentistry  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","first-page":"18","article-title":"Current Dental Implant Design and Its Clinical Importance","volume":"35","author":"Ye L.","year":"2017","journal-title":"Hua Xi Kou Qiang Yi Xue Za Zhi"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034518792567"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-023-04942-2"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.9.1412"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12017"},{"issue":"1","key":"e_1_2_10_7_1","first-page":"11","article-title":"The Long\u2010Term Efficacy of Currently Used Dental Implants: A Review and Proposed Criteria of Success","volume":"1","author":"Albrektsson T.","year":"1986","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13122"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02557.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120592"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12334"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-020-1019-7"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0236"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2002.130101.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01275.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.4.546"},{"key":"e_1_2_10_17_1","first-page":"43","article-title":"Optimizing Esthetics for Implant Restorations in the Anterior Maxilla: Anatomic and Surgical Considerations","volume":"19","author":"Buser D.","year":"2004","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12042"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13135"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12412"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.6809"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2015.09.001"},{"issue":"3","key":"e_1_2_10_23_1","first-page":"166","article-title":"Immediate Placement of Dental Implants in Molar Extraction Sockets: An 11\u2010Year Retrospective Analysis","volume":"40","author":"Smith R. 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