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Samples were analyzed using multiplex\u2010immunoassay panel consisting of inflammatory mediators in the tumor necrosis factor (TNF), interferon (IFN), interleukin (IL) superfamily, and matrix metalloproteinases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The levels of B\u2010cell activating factor (BAFF), sIL\u20106R\u03b2, IFN\u2010\u03b2, and sIL\u20106R\u03b1, sTNFR1, and Pentraxin\u20103 were significantly higher in patients with periodontitis and\/or peri\u2010implantitis compared to healthy subjects. Furthermore, among the investigated inflammatory mediators, Pentraxin\u20103 exhibited the highest diagnostic potential (AUC\u2009=\u20090.74) for distinguishing between subjects with periodontitis and\/or peri\u2010implantitis and healthy individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings demonstrated elevated salivary levels of BAFF, sIL\u20106R\u03b2, IFN\u2010\u03b2, sIL\u20106R\u03b1, sTNF\u2010R1, and Pentraxin\u20103 in individuals with periodontitis and\/or peri\u2010implantitis in comparison to periodontal and peri\u2010implant healthy controls.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cid.70002","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T01:20:26Z","timestamp":1738113626000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Salivary Inflammatory Mediator Profiles in Periodontal and Peri\u2010Implant Health and Disease: A Cross\u2010Sectional Study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0419-016X","authenticated-orcid":false,"given":"Carl","family":"Titusson","sequence":"first","affiliation":[{"name":"Department of Dental Medicine, Division of Pediatric Dentistry Karolinska Institutet  Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5923-5777","authenticated-orcid":false,"given":"Leif","family":"Jansson","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, Division of Periodontology Karolinska Institutet  Huddinge Sweden"},{"name":"Folktandv\u00e5rden Eastmaninstitutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6729-3990","authenticated-orcid":false,"given":"Carolina","family":"Modin","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, Division of Periodontology Karolinska Institutet  Huddinge Sweden"},{"name":"Folktandv\u00e5rden Eastmaninstitutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3655-3710","authenticated-orcid":false,"given":"Anna","family":"Lundmark","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, Division of Pediatric Dentistry Karolinska Institutet  Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9490-8540","authenticated-orcid":false,"given":"Kaja","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, Division of Pediatric Dentistry Karolinska Institutet  Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lottie","family":"Adler","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, Division of Periodontology Karolinska Institutet  Huddinge Sweden"},{"name":"Folktandv\u00e5rden Eastmaninstitutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0129-8809","authenticated-orcid":false,"given":"T\u00fclay","family":"Yucel\u2010Lindberg","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, Division of Pediatric Dentistry Karolinska Institutet  Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3785"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma11101802"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12104"},{"issue":"4","key":"e_1_2_11_5_1","first-page":"299","article-title":"Tissue Destruction in Periodontitis: Bacteria or Cytokines Fault?","volume":"36","author":"Bascones A.","year":"2005","journal-title":"Quintessence International"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12296"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010018\u20100089\u2010x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12323"},{"issue":"2","key":"e_1_2_11_9_1","first-page":"69","article-title":"Oral Health of Individuals Aged 3\u201380\u2009Years in J\u00f6nk\u00f6ping, Sweden During 40\u2009Years (1973\u20132013). 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