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However, risks and complications still exist with this procedure including pain, bleeding, infection, oroantral communication, and inadequate bone regeneration for implant placement. To decrease some of these potential complications and improve outcomes, biologics are becoming more widely used in maxillary sinus augmentation. Autologous blood concentrates (ABCs) can be utilized as a membrane to seal a sinus membrane perforation or as \u201csticky bone\u201d to mix with particulate material to make a congealed bone graft that will stay in place and be less likely to migrate from the site of placement or into the sinus cavity. Although the data is heterogeneous and somewhat conflicting, there is some evidence to support the use of ABCs for bone graft consolidation and overall wound healing due to the growth factors contained in the ABC. In addition, clotting factors in the plasma aid in hemostasis, which is an essential first step in the wound healing cascade. Individual growth factors such as rhBMP\u20102 and rhPDGF\u2010BB are also clinically available for use in bone grafting procedures such as MSFA. rhBMP\u20102 is FDA approved for maxillary sinus augmentation, and clinical trials demonstrate de novo bone formation to facilitate dental implant placement. However, studies do not show a significant improvement over autogenous bone or bone substitutes such as xenograft or allografts. rhPDGF\u2010BB has limited studies in this area, but may decrease residual particulate graft material and aid in increasing vital bone when bone substitutes are used. However, the use for MSFA is \u201coff label\u201d and few studies are available. Finally, enamel matrix derivative (EMD) has no data, and therefore, limited use for MFSA.<\/jats:p>","DOI":"10.1111\/cid.70004","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T10:04:32Z","timestamp":1749117872000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Application of Biologics in Maxillary Sinus Augmentation Surgery: A Narrative Review"],"prefix":"10.1111","volume":"27","author":[{"given":"Tara","family":"Aghaloo","sequence":"first","affiliation":[{"name":"School of Dentistry, Department of Oral and Maxillofacial Surgery University of California Los Angeles (UCLA)  California Los Angeles USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2712-8819","authenticated-orcid":false,"given":"Pascal","family":"Valentini","sequence":"additional","affiliation":[{"name":"Institute of Health University of Corsica Pasquale Paoli  Corte France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reule","family":"Yardley","sequence":"additional","affiliation":[{"name":"School of Dentistry, Department of Oral and Maxillofacial Surgery University of California Los Angeles (UCLA)  California Los Angeles USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7770-9363","authenticated-orcid":false,"given":"Homayoun H.","family":"Zadeh","sequence":"additional","affiliation":[{"name":"VISTA Institute for Therapeutic Innovations  Woodland Hills California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13436"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.3865"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12521"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12701"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12687"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13055"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.16suppl.g1"},{"key":"e_1_2_7_9_1","first-page":"49","article-title":"Which Hard Tissue Augmentation Techniques Are the Most Successful in Furnishing Bony Support for Implant Placement?","volume":"22","author":"Aghaloo T. 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