{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T03:41:08Z","timestamp":1792381268886,"version":"4.4.0"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In this update of a previous systematic review, we compared the effects of surgical and non\u2010surgical treatments for peri\u2010implantitis through the component network meta\u2010analysis (CNMA) with probing depth (PD) reduction as the outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Literature search was conducted in PubMed, Cochrane Central Register of Controlled Trials, and Embase databases from August 2010 to June 2023. Randomized controlled trials (RCTs), comparing non\u2010surgical or surgical treatments for peri\u2010implantitis with 6\u201312\u2009months of follow\u2010up and reported changes in PD, were included. Treatment effects were assessed using a CNMA model based on additivity assumption. We calculated the intraclass correlation coefficient (ICC) to adjust the standard errors for multiple implants within the same patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our systematic review identified 44 RCTs, which included 46 treatment regimens consisting of 15 components. These RCTs formed a disconnected network consisting of 11 subnetworks. Surgical treatments with bone grafts and membranes generally attained greater PD reduction than non\u2010surgical treatments, although bone grafts and membranes as components provided moderate benefits. The effect size of antibiotics is greater in non\u2010surgical than surgical treatments, while there is considerable uncertainty regarding the effect size of implantoplasty. Additionally, the effectiveness of components varied between surgical and non\u2010surgical treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Current evidence does not yield sufficiently robust estimates for identifying optimal surgical and non\u2010surgical treatment regimens for peri\u2010implantitis, so the findings of our study should be interpreted cautiously. A coordinated strategy is required for designing future trials to fill the gaps in our current knowledge and develop more reliable recommendations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cid.70010","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T23:44:46Z","timestamp":1739490286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Probing Depth Reduction Following Peri\u2010Implantitis Treatment: A Systematic Review and Component Network Meta\u2010Analysis"],"prefix":"10.1111","volume":"27","author":[{"given":"Yun\u2010Chen","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Health Data Analytics and Statistics, College of Public Health National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yih\u2010Yun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Public Health, College of Public Health National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Simonelli","sequence":"additional","affiliation":[{"name":"Research Centre for the Study of Periodontal and Peri\u2010Implant Diseases, and Operative Unit of Dentistry Azienda Unit\u00e0 Sanitaria Locale (A.U.S.L.) of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4621-7809","authenticated-orcid":false,"given":"Roberto","family":"Farina","sequence":"additional","affiliation":[{"name":"Research Centre for the Study of Periodontal and Peri\u2010Implant Diseases, and Operative Unit of Dentistry Azienda Unit\u00e0 Sanitaria Locale (A.U.S.L.) of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Trombelli","sequence":"additional","affiliation":[{"name":"Research Centre for the Study of Periodontal and Peri\u2010Implant Diseases, and Operative Unit of Dentistry Azienda Unit\u00e0 Sanitaria Locale (A.U.S.L.) of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8129-6701","authenticated-orcid":false,"given":"Chen\u2010Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Dentistry, College of Medicine, National Taiwan University, and Department of Dentistry National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2461-474X","authenticated-orcid":false,"given":"Yu\u2010Kang","family":"Tu","sequence":"additional","affiliation":[{"name":"Institute of Health Data Analytics and Statistics, College of Public Health, and Health Data Research Center National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120592"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2017.04.011"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-022-02493-8"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.16-0350"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13823"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2011.00384.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12292"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bimj.201800167"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-023-02956-6"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13162"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"e_1_2_9_13_1","article-title":"Chapter\u00a023: Including Variants on Randomized Trials","author":"Higgins J. 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