{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T03:41:21Z","timestamp":1792381281467,"version":"4.4.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate perfusion parameters and clinical features of healthy implants and implants affected by peri\u2010implant disease in patients who had undergone microvascular jaw reconstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 25 patients with 92 implants placed in microvascular transplants were included. Of these, 68 implants showed healthy peri\u2010implant tissue, 12 were affected by peri\u2010implant mucositis, and 12 were diagnosed with peri\u2010implantitis. Peri\u2010implant perfusion was measured mesially and distally at the implant shoulder using laser Doppler flowmetry and tissue spectrophotometry (LDF\u2010TS), followed by a clinical evaluation, including measurement of probing depths, bleeding on probing (BOP), plaque index, biotype, type of implant, the restoration and the presence of keratinized tissue. Perfusion parameters were compared between the healthy implants and the implants with peri\u2010implant disease based on the conventional BOP\u2013based diagnosis of peri\u2010implantitis, and the associations between the perfusion values and clinical measurements were analyzed. Optimal cut\u2010off values for predicting peri\u2010implantitis were calculated with receiver operating characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean relative amount of hemoglobin and mean blood flow were significantly different between healthy implants and implants with peri\u2010implant mucositis and peri\u2010implantitis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002, respectively). However, there are interindividual differences that appear to influence blood flow values as well. When a linear mixed regression model was applied, including the patient as a random variable, the difference in blood flow was no longer statistically significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.400). Still, the optimal cut\u2010off value of mean blood flow for predicting peri\u2010implantitis was determined to be &gt;\u200946.5\u2009AU (AUC\u2009=\u20090.788;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; CI\u2009=\u20090.695\u20130.881; sensitivity\u2009=\u20091.00, specificity\u2009=\u20090.60).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Implants in microvascular flaps are particularly vulnerable to peri\u2010implant disease. Risk factors are the lack of keratinized peri\u2010implant tissue, fixed restorations, bone\u2010level implants, and high plaque levels.<\/jats:p>\n                    <jats:p>As a noninvasive and objective method, LDF\u2010TS can contribute to risk assessment by evaluating perfusion parameters and help detect the early onset of peri\u2010implant disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cid.70012","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T06:44:06Z","timestamp":1739342646000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Peri\u2010Implant Health and Perfusion Parameters in Patients After Microvascular Jaw Reconstruction: A Clinical Cohort Study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6625-7712","authenticated-orcid":false,"given":"Marie Sophie","family":"Katz","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Ooms","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Heitzer","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bock","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Vohl","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Kniha","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"H\u00f6lzle","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Modabber","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital RWTH Aachen  Aachen 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