{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:32:08Z","timestamp":1791912728445,"version":"4.3.4"},"reference-count":56,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Early marginal bone loss (EMBL) is a non\u2010infective phenomenon occurring around the implant neck from placement to the first year of prosthetic function, being influenced by both surgical and prosthetic factors. This multi\u2010center prospective study assesses the impact of different variables potentially influencing marginal bone stability during the period from crown delivery to 18\u2009months of functional loading.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010seven patients requiring a single posterior mandibular implant were selected according to specific criteria. Tissue\u2010level implants were placed at different crestal bone levels based on vertical mucosal thickness and followed in an unsubmerged healing protocol, as described in a previous study evaluating peri\u2010implant bone levels (PBL) from implant placement (T0) to crown delivery (T1). The present study continues this evaluation, focusing on MBL from T1 to 18\u2009months post\u2010loading (T2). Host\u2010related factors (age, gender, smoking, history of periodontitis, vertical mucosal thickness) and specific prosthetic parameters, including crown mesio\u2010distal dimension, emergence angle, and transmucosal collar height were recorded. Multiple linear regression analysis explored associations between MBL and prosthetic or patient\u2010related factors, with significance set at <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Marginal bone levels remained stable from T1 to T2, with no significant association between MBL and host\u2010related factors or defined prosthetic variables. However, total MBL from T0 to T2 was significantly higher around implants with thin mucosa at T0 compared to medium and thick mucosa. Multivariate analysis (T0\u2010T2) identified thin mucosa and smoking as significant MBL predictors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>From T1 to T2, marginal bone levels around tissue\u2010level implants remain stable, with no significant influence from variables analyzed. Conversely, peri\u2010implant bone resorption between T0 and T2 is significantly associated with thin mucosa (primarily affecting T0\u2010T1) and smoking.<\/jats:p><jats:p><jats:bold>Trial Registration:<\/jats:bold> <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.clinicaltrials.gov\/\">www.clinicaltrials.gov<\/jats:ext-link>: NCT05363306<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.70071","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T01:39:58Z","timestamp":1749692398000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Marginal Bone Changes Around Tissue\u2010Level Implants After Prosthesis Delivery: A Multicenter Prospective Study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9014-8732","authenticated-orcid":false,"given":"Sergio","family":"Spinato","sequence":"first","affiliation":[{"name":"Private Practice  Sassuolo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6432-1549","authenticated-orcid":false,"given":"Fabio","family":"Bernardello","sequence":"additional","affiliation":[{"name":"Private Practice  Legnago Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4017-4980","authenticated-orcid":false,"given":"Claudio","family":"Stacchi","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Health Sciences University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4618-5541","authenticated-orcid":false,"given":"Carlo 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