{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T14:20:54Z","timestamp":1773930054939,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare a dPTFE membrane to a collagen membrane in guided bone regeneration (GBR) for horizontal bone augmentation at single sites in the anterior maxilla in terms of alveolar width and bone quality, as clinically and histologically assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Patients with a class 4 defect (Benic and H\u00e4mmerle 2014) at a single site in the anterior maxilla (15\u201325) were recruited in five centers. Following flap elevation and conditioning of the recipient site, they were randomly allocated to the dPTFE membrane group or the collagen membrane group. All patients were treated with a 1:1 mixture of autogenous bone and DBBM. Nine months following bone augmentation, re\u2010entry was performed, intra\u2010surgical clinical measurements were registered, and core biopsies were obtained for histological analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010six patients were randomized (dPTFE membrane group: 8 females, 10 males, mean age 39; collagen membrane group: 14 females, 4 males, mean age 51) and all but one underwent re\u2010entry. GBR was effective in both groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) yet followed a different pattern over time (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010) with a higher postoperative alveolar width in the collagen membrane group followed by more graft resorption. At re\u2010entry, the estimated marginal mean alveolar width was 7.0\u2009mm in the dPTFE membrane group and 6.5\u2009mm in the collagen membrane group at re\u2010entry, without statistically significant differences between the groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.326). However, infection occurred in 6\/18 patients treated with a dPTFE membrane group versus in none treated with a collagen membrane. Clinical assessment at re\u2010entry identified fibrous tissue at the buccal aspect in 7\/18 (39%) patients treated with a dPTFE membrane and in 8\/17 (47%) patients treated with a collagen membrane, without statistically significant differences between the groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.738). Histomorphometric analyses showed newly formed bone in both groups (&gt;\u200930%) and a minimal amount of DBBM particles (~5%), mostly being in intimate contact with surrounding newly formed bone (~70%). The non\u2010mineralized tissue fraction was 5% higher in the dPTFE membrane group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020). There were no significant differences between the groups for other histological outcome measures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Alveolar width enabled implant installation at 9\u2009months in both groups, yet dPTFE membrane was prone to infection. In both groups, fibrous tissue at the buccal aspect was common and newly formed bone was consistently observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT05426616.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cid.70097","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T06:21:02Z","timestamp":1762237262000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Multi\u2010Center\n                    <scp>RCT<\/scp>\n                    Comparing Titanium\u2010Reinforced\n                    <scp>dPTFE<\/scp>\n                    Membrane to Collagen Membrane in Horizontal Bone Augmentation at Single Sites in the Anterior Maxilla: Clinical and Histological Outcomes"],"prefix":"10.1111","volume":"27","author":[{"given":"Matthijs","family":"Hindryckx","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Oral Health Sciences, Department of Periodontology and Oral Implantology Ghent University  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9051-2541","authenticated-orcid":false,"given":"Thomas","family":"De Bruyckere","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Oral Health Sciences, Department of Periodontology and Oral Implantology Ghent University  Ghent Belgium"},{"name":"Private Practice ImplantoParo SPL  Sint\u2010Pieters\u2010Leeuw Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja","family":"Hitz\u2010Steiger","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center for Dental Medicine University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenz","family":"Seyssens","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Oral Health Sciences, Department of Periodontology and Oral Implantology Ghent University  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Retis","family":"Shtino","sequence":"additional","affiliation":[{"name":"Private Practice Orthodontie en Parodontologie Merelbeke  Merelbeke Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faris","family":"Younes","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Oral Health Sciences, Department of Periodontology and Oral Implantology Ghent University  Ghent Belgium"},{"name":"Private Practice ImplantoParo  Roeselare Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1764-7447","authenticated-orcid":false,"given":"Daniel","family":"Thoma","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center for Dental Medicine University of Zurich  Zurich Switzerland"},{"name":"Department of Periodontology Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5042-2875","authenticated-orcid":false,"given":"Jan","family":"Cosyn","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Oral Health Sciences, Department of Periodontology and Oral Implantology Ghent University  Ghent Belgium"},{"name":"Private Practice Centrum voor Parodontologie en Orale 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