{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T14:21:09Z","timestamp":1773930069813,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Dental implants are widely utilized to manage both partially and completely edentulous older patients. However, such patients often present with multiple systemic diseases and may be at an increased risk of complications before and after implant surgery. Nevertheless, population\u2010level data on systemic diseases and medication use in these patients remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective, cross\u2010sectional study analyzed 36\u2009957 patients who underwent 43\u2009171 insurance\u2010covered implant surgeries between 2014 and 2019 using the National Health Insurance Service\u2010National Sample Cohort (NHIS\u2010NSC) database. Patients aged 65\u2009years or older were included. Sociodemographic characteristics, diagnosis of systemic diseases within 1\u2009year before implant surgery, medication history, and type of medical institution were evaluated. Additionally, logistic regression analysis was performed to investigate factors associated with implant removal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 36\u2009957 patients who underwent 43\u2009171 implant surgeries, implant removal occurred in 803 patients. Within 1\u2009year before surgery, 89.33% had at least one systemic disease, including hypertension (57.92%), arthritis (43.39%), and diabetes (34.62%). Antithrombotic and antiresorptive agents were prescribed to 6.77% and 5.05% of patients, respectively. The use of intravenous (IV) bisphosphonates, denosumab, and direct oral anticoagulants (DOACs) increased, whereas the use of oral bisphosphonates and warfarin decreased. Logistic regression analysis showed that cerebrovascular and kidney disease increased the risk of implant removal, whereas osteoporosis and antiresorptive agents decreased the risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Most older patients who underwent implant surgery had systemic diseases, and approximately 10% were prescribed medications. Cerebrovascular and kidney diseases increased the risk of implant removal, whereas osteoporosis or antiresorptive therapy decreased the risk. With the increasing use of DOACs, IV bisphosphonates, and denosumab, clinicians carefully review the medical histories of older implant patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cid.70104","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T11:01:13Z","timestamp":1765278073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic Conditions and Medication Use in Older Patients Undergoing Dental Implants: A Nationwide Cross\u2010Sectional Study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0603-619X","authenticated-orcid":false,"given":"Jaeyeon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Advanced General Dentistry, College of Dentistry Yonsei University  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5514-187X","authenticated-orcid":false,"given":"Jisun","family":"Huh","sequence":"additional","affiliation":[{"name":"Department of Dental Education, College of Dentistry Yonsei University  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8594-4611","authenticated-orcid":false,"given":"Geun U.","family":"Park","sequence":"additional","affiliation":[{"name":"GN  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6596-6135","authenticated-orcid":false,"given":"Jun\u2010Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, College of Dentistry Yonsei University  Seoul Korea"},{"name":"Yonsei Institute for Digital Health Yonsei University  Seoul 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Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13288"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.22974\/jkda.2019.57.9.001"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz201"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13412"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13307"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.17245\/jdapm.2017.17.2.113"},{"issue":"2","key":"e_1_2_11_8_1","first-page":"e15","article-title":"Cohort Profile: The National Health Insurance Service\u2010National Sample Cohort (NHIS\u2010NSC), South Korea","volume":"46","author":"Lee J.","year":"2017","journal-title":"International Journal of 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