{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:30:26Z","timestamp":1791214226784,"version":"4.1.0"},"reference-count":235,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To systematically review the updated evidence for the clinical outcome of fixed implant prostheses treated with different combinations of implant placement and loading protocols in partially edentulous patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>An electronic search was performed in Medline, Embase, and Central to identify studies of implants subjected to immediate placement + immediate restoration\/loading (Type 1A), immediate placement + early loading (Type 1B), immediate placement + conventional loading (Type 1C), early placement + immediate restoration\/loading (Type 2\u20133A), early placement + early loading (Type 2\u20133B), early placement + conventional loading (Type 2\u20133C), late placement + immediate restoration\/loading (Type 4A), late placement + early loading (Type 4B), late placement + conventional loading (Type 4C) with implant\u2010supported fixed dental prostheses (IFDPs) in partially edentulous patients. A cumulative survival rate for each type of the implant placement and loading protocols was weighted by the duration of follow\u2010up and number of implants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 11\u2009427 records, 140 studies (42 RCTs; 98 CCTs\/cohort studies) encompassing 10\u2009456 implants met the criteria. Weighted cumulative survival rates for each protocol were: 98.0% (Type 1A), 91.6% (Type 1B), 95.0% (Type 1C), 97.8% (Type 2\u20133A), 100% (Type 2\u20133B), 94.0% (Type 2\u20133C), 97.2% (Type 4A), 97.9% (Type 4B), 97.5% (Type 4C). Protocols 1A, 1C, 2\u20133C, 4A, 4B, and 4C satisfy scientific and\/or clinical validation thresholds, whereas 1B and 2\u20133B remain insufficiently documented despite high numeric survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In immediate placement, Type 1C shows strong survival rates. It is considered scientifically and clinically validated, while Type 1A also meets the criteria for a scientifically and clinically validated protocol with high survival rates. Meanwhile, Type 1B continues to show lower and more variable survival rates\u2014being clinically documented\u2014underscoring the need for careful case selection. Regarding early placement, Type 2\u20133C is recognized as a scientifically and clinically validated protocol. Type 2\u20133A, which was previously underreported, now demonstrates similarly validated survival rates that expand the evidence for early implant placement with immediate loading. Although Type 2\u20133B is clinically documented, it still lacks sufficient evidence. All late implant placement protocols are considered scientifically and clinically validated: Type 4C offers high survival with long\u2010term predictability, while Type 4A and Type 4B maintain stable survival rates backed by well\u2010established evidence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cid.70120","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:36:28Z","timestamp":1769164588000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Current State of Evidence for Implant Placement and Loading in Partially Edentulous Patients: A Systematic Review"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6386-594X","authenticated-orcid":false,"given":"German O.","family":"Gallucci","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry and Biomaterials Sciences Harvard School of Dental Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1523-1904","authenticated-orcid":false,"given":"Adam","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry and Biomaterials Sciences Harvard School of Dental Medicine  Boston Massachusetts USA"},{"name":"Division of Oral Restorative and Rehabilitative Sciences University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6238-3236","authenticated-orcid":false,"given":"Samuel","family":"Akhondi","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry and Biomaterials Sciences Harvard School of Dental Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5243-6777","authenticated-orcid":false,"given":"Kevser","family":"Pala","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry and Biomaterials Sciences Harvard School of Dental Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7871-0251","authenticated-orcid":false,"given":"Juan Francisco","family":"Pe\u00f1a\u2010Cardelles","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry and Biomaterials Sciences Harvard School of Dental Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13276"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14109"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13183"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14137"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14172"},{"key":"e_1_2_10_8_1","first-page":"186","article-title":"Clinical and Esthetic Outcomes of Implants Placed in Postextraction Sites","volume":"24","author":"Chen S. 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