{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:42:59Z","timestamp":1784889779511,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>A study was made to assess the diagnostic and predictive value of bleeding on probing (BoP) and the modified Bleeding Index (mBI) for identifying progressive peri\u2010implant bone loss over a 24\u2010month period in patients enrolled in supportive peri\u2010implant care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A prospective cohort study was carried out of 59 patients with screw\u2010retained implant\u2010supported prostheses followed\u2010up on for 24\u2009months. Clinical parameters, including BoP, mBI, probing depth and plaque index, were recorded at six sites per implant across five follow\u2010up visits. Progressive peri\u2010implant bone loss was defined as \u2265\u20090.5\u2009mm of marginal bone loss as assessed radiographically. The longitudinal diagnostic performance of the bleeding indices was evaluated using sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and receiver operating characteristic (ROC) analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After 24\u2009months, 9 of 59 implants (15.3%) demonstrated progressive bone loss. Both BoP and mBI showed high sensitivity (88.9%\u2013100%) but low specificity (0%\u201326%) for detecting bone loss. PPV was low (16%\u201318%), whereas NPV remained high (91%\u2013100%). Recurrent low\u2010grade bleeding (mBI\u2009=\u20091) observed across multiple visits was more strongly associated with progressive bone loss than isolated episodes of severe bleeding. Consistent absence of bleeding was associated with peri\u2010implant stability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients receiving supportive peri\u2010implant care, the absence of bleeding is a reliable indicator of peri\u2010implant health. While bleeding assessed at a single timepoint has limited specificity, longitudinal patterns of mild bleeding are of greater value in predicting disease progression, highlighting the importance of regular monitoring and of standardized clinical assessment protocols. This prospective cohort study was not registered prior to participant recruitment and randomization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cid.70138","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T10:53:25Z","timestamp":1774349605000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bleeding on Probing as a Predictor of Peri\u2010Implant Bone Loss During Supportive Care: A Prospective Cohort Study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5542-7659","authenticated-orcid":false,"given":"Beatriz","family":"de Tapia","sequence":"first","affiliation":[{"name":"Department of Periodontics Universitat Internacional de Catalunya  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Torrens","sequence":"additional","affiliation":[{"name":"Department of Periodontics Universitat Internacional de Catalunya  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"di Leone","sequence":"additional","affiliation":[{"name":"Department of Periodontics Universitat Internacional de Catalunya  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ettore","family":"Amerio","sequence":"additional","affiliation":[{"name":"Department of Periodontics Universitat Internacional de Catalunya  Barcelona Spain"},{"name":"Department of Biomedical, Surgical and Dental Sciences, Unit of Periodontology University of Milan  Milan Italy"},{"name":"Fondazione IRCCS Ca' Granda Polyclinic  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2690-1208","authenticated-orcid":false,"given":"Cristina","family":"Valles","sequence":"additional","affiliation":[{"name":"Department of Periodontics Universitat Internacional de Catalunya  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2363-4992","authenticated-orcid":false,"given":"Jose","family":"Nart","sequence":"additional","affiliation":[{"name":"Department of Periodontics Universitat Internacional de Catalunya  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8292-1927","authenticated-orcid":false,"given":"Alberto","family":"Monje","sequence":"additional","affiliation":[{"name":"Department of Periodontics Universitat Internacional de Catalunya  Barcelona Spain"},{"name":"Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12369"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13823"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12957"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2009.01415.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jebdp.2024.102034"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13127"},{"issue":"4","key":"e_1_2_11_8_1","first-page":"385","article-title":"Significance of Probing for Monitoring Peri\u2010Implant Diseases","volume":"14","author":"Monje A.","year":"2021","journal-title":"International Journal of Oral Implantology"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u2010302X.1987.tb00298.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.4932"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1981.52.5.260"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515608832"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.1990.tb01059.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.1994.tb00737.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100501.1996.070207.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13356"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100501.2000.011006521.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2008.01601.x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jper.23\u20100048"}],"container-title":["Clinical Implant Dentistry and Related Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cid.70138","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cid.70138","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cid.70138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T09:55:22Z","timestamp":1779443722000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cid.70138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,24]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/cid.70138"],"URL":"https:\/\/doi.org\/10.1111\/cid.70138","archive":["Portico"],"relation":{},"ISSN":["1523-0899","1708-8208"],"issn-type":[{"value":"1523-0899","type":"print"},{"value":"1708-8208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,24]]},"assertion":[{"value":"2026-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70138"}}