{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:30:57Z","timestamp":1787761857303,"version":"build-2784847793"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The objective of this ex\u00a0vivo investigation was to study the significance of barrier membrane application on graft stability across different peri\u2010implantitis\u2010related bone defect configurations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Fresh pig mandibles were used to create standardized peri\u2010implant\u2010like bone defects, including dehiscence defects, 2\u20133 wall defects, and circumferential defects. Defects were treated using identical grafting and flap closure protocols, with or without barrier membrane application. High\u2010resolution cone\u2010beam computed tomography (CBCT) scans were obtained before flap closure, after primary closure, and following simulated soft\u2010tissue movement in order to analyze graft material thickness at multiple predefined levels along the implant surface. Changes in graft thickness over time were analyzed using generalized estimating equation (GEE) linear regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 120 bone augmentation procedures in 20 pig hemimandibles were analyzed. In dehiscence defect morphologies, graft thickness decreased significantly over time, with the greatest dimensional changes occurring immediately after primary wound closure (GEE main effect of TIME,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In these defects, pronounced coronal (platform level) graft displacement was observed, with thickness reductions of approximately 1.2\u20131.4\u2009mm after closure and total reductions exceeding 85% following simulated soft\u2010tissue movement. Barrier membrane application did not prevent graft collapse nor modify the coronal temporal pattern; however, it resulted in a limited attenuation of graft loss at selected middle levels (approximately 0.15\u20130.25\u2009mm, corresponding to 5%\u201315% relative reduction). In 2\u20133 wall defects, graft thickness also decreased significantly over time across all evaluated levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with membrane application consistently attenuating early graft displacement at coronal and middle levels. In contrast, circumferential defects demonstrated high intrinsic dimensional stability, with minimal dimensional changes over time (&lt;\u20090.1\u2009mm) and no significant membrane\u2010related effects. Across defect types exhibiting graft displacement, coronal measurements consistently showed the greatest susceptibility to thickness reduction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Graft stability following reconstructive therapy of peri\u2010implantitis\u2010like bone defects is primarily influenced by defect morphology. Hence, the effect of barrier membrane coverage appears to be defect\u2010dependent. Membrane application provides limited attenuation of graft displacement in 2\u20133 wall defects while no consistent or clinically meaningful additional effect is observed in dehiscence or circumferential defects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cid.70140","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T10:26:57Z","timestamp":1774952817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Influence of Barrier Membrane and Peri\u2010Implantitis\u2010Like Bone Defect Configurations on Graft Stability"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0416-7380","authenticated-orcid":false,"given":"Fernando","family":"Su\u00e1rez","sequence":"first","affiliation":[{"name":"School of Dentistry Universidad Cat\u00f3lica de Santiago de Guayaquil (UCSG)  Guayaquil Ecuador"},{"name":"Department of Periodontics The University of Iowa College of Dentistry  Iowa Iowa USA"},{"name":"Private Practice  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9989-4483","authenticated-orcid":false,"given":"Emilio","family":"Couso\u2010Queiruga","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Stomatology University of Bern School of Dental Medicine  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Osorio","sequence":"additional","affiliation":[{"name":"Department of Periodontology CICOM MONJE Institute  Badajoz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Blasi","sequence":"additional","affiliation":[{"name":"Department of Periodontology Universitat Internacional de Catalunya  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8292-1927","authenticated-orcid":false,"given":"Alberto","family":"Monje","sequence":"additional","affiliation":[{"name":"Department of Periodontology CICOM MONJE Institute  Badajoz Spain"},{"name":"Department of Periodontology Universitat Internacional de Catalunya  Barcelona Spain"},{"name":"Department of Periodontology University of Bern School of Dental Medicine  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0739"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2025.105914"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0b013e3182a2b8f4"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12523"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01540.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2006.01320.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12791"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13434"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13393"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13583"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12417"},{"issue":"1","key":"e_1_2_11_13_1","first-page":"115","article-title":"Disease Resolution Following the Treatment of Peri\u2010Implant Diseases: A Systematic Review","volume":"45","author":"Garaicoa\u2010Pazmino C.","year":"2025","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12460"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13028"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb16070262"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12661"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.70057"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.22-0511"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12510"},{"key":"e_1_2_11_21_1","first-page":"1","article-title":"The Effect of Defect Morphology and Membrane Fixation on 3D Graft Material Displacement During Primary Wound Closure in Horizontal Bone Augmentation\u2010An Ex\u00a0Vivo Study","volume":"37","author":"Raabe C.","year":"2025","journal-title":"Clinical Oral Implants Research"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13665"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12590"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02554.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-025-06692-x"}],"container-title":["Clinical Implant Dentistry and Related 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