{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T10:07:48Z","timestamp":1779444468130,"version":"3.53.1"},"reference-count":63,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate for the first time the difference in Yes\u2010associated protein (YAP) gene expression and protein levels in the peri\u2010implant crevicular fluid of healthy osseointegrated titanium implants and those showing early signs of peri\u2010implantitis before loading; and to investigate the immunomodulatory effect of titanium on YAP expression by comparing YAP protein levels around healthy implants with those in the gingival crevicular fluid of healthy teeth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010six systemically healthy individuals were recruited. Fold change in\n                      <jats:italic>YAP<\/jats:italic>\n                      gene expression was evaluated by q\u2010PCR, and YAP protein level was measured by ELISA in clinical conditions of peri\u2010implant health (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922) and peri\u2010implantitis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922) before insertion of implant\u2010supported prosthesis to avoid the effect of loading on mechanosensitive YAP. The level of YAP protein was measured in healthy periodontal tissues (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922) in the absence of traumatic occlusion and compared with healthy peri\u2010implant environment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Statistical analysis revealed that\n                      <jats:italic>YAP<\/jats:italic>\n                      gene expression relatively increased by 35% in the presence of peri\u2010implantitis with a non\u2010significant\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value of 0.938. YAP protein levels pairwise comparison between the studied groups was statistically significant with\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value &lt;\u20090.005. The least value of YAP was in healthy periodontium, followed by healthy peri\u2010implant tissue and finally a remarkable increase in the presence of peri\u2010implantitis. Gender was a significant predictor of YAP, with higher levels in females in the presence of implants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>YAP is a recent biomarker that can predict the presence of inflammation in the peri\u2010implant environment. YAP protein levels are the highest in the presence of titanium implants and early clinical and radiographic signs of peri\u2010implantitis. Studying the YAP\u2010related osteoimmunology of the peri\u2010implant environment offers new insights into a better understanding of the osseointegration process and titanium\u2010induced peri\u2010implantitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cid.70148","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T01:30:41Z","timestamp":1776821441000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the Estimated Role of Yes\u2010Associated Protein in the Etiology of Peri\u2010Implantitis: A Case\u2013Control Study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4023-3653","authenticated-orcid":false,"given":"Samar Mohamed","family":"Emam","sequence":"first","affiliation":[{"name":"Faculty of Dentistry  Alexandria Egypt"},{"name":"Institute of Graduate Studies and Research  Alexandria 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