{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:16:39Z","timestamp":1788513399893,"version":"build-2803163510"},"reference-count":97,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011970","name":"International Team for Implantology","doi-asserted-by":"publisher","award":["1574\u20102021"],"award-info":[{"award-number":["1574\u20102021"]}],"id":[{"id":"10.13039\/501100011970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess 25\u2010year implant survival, success rates, peri\u2010implant conditions, and variables influencing peri\u2010implant mucositis (PM), peri\u2010implantitis (PI), and loss of osseointegration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Partially edentulous patients rehabilitated with tissue\u2010level implant\u2010supported prostheses were evaluated. Calibrated examiners performed clinical and radiographic assessments, and potential variables for PM and PI were analyzed at the final follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At the 10\u2010 and 25\u2010year follow\u2010ups, 303 and 159 patients with 511 and 252 implants, respectively, were included. Implant failure (IF) was 1.2% at 10\u2009years and 6.0% at 25\u2009years, with implant survival rates of 98.8% and 94.0%, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Implant success rates ranged from 97.0% at 10\u2009years to 90.8% at 25\u2009years (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). IF due to loss of osseointegration increased from 0.6% to 3.6% at the implant level and from 1.0% to 2.5% at the patient level, and were located only in premolar or molar sites. At implant level, peri\u2010implant health (PH) was 14.4% at 10 and 25\u2009years (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.00), while PM decreased from 82.1% to 76.5% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.08), and PI increased from 3.5% to 9.1% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). At patient level, PH remained stable between 10 and 25\u2009years, ranging from 10.0% to 10.3% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.94), while PM decreased from 80.0% to 71.6% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.06), and PI increased from 10.0% to 18.1% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). In the multivariate analysis, history of periodontitis (OR\u2009=\u20093.87) and facial mucosal thickness (OR\u2009=\u20090.42) were associated with PM, whereas facial mucosal thickness was associated with PI (OR\u2009=\u20090.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>After 25\u2009years, implant survival and success exceeded 90%. Loss of osseointegration accounted for approximately 60% of IF. While PI and IF increased over time, PM decreased but remained prevalent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cid.70171","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:57:18Z","timestamp":1783598238000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010Term Incidence of Peri\u2010Implant Conditions: 25\u2010Year Results of The Bernese Prospective Cohort Study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9989-4483","authenticated-orcid":false,"given":"Emilio","family":"Couso\u2010Queiruga","sequence":"first","affiliation":[{"name":"Department of Oral Surgery and Stomatology University of Bern School of Dental Medicine  Bern 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