{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:09:52Z","timestamp":1790352592911,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate survival rates and identify temporally distinct risk factors for early and late failure of wide\u2010diameter dental implants (\u2265\u20095.0\u2009mm) in a large real\u2010world cohort using landmark analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study analyzed 12\u2009041 wide\u2010diameter implants (\u2265\u20095.0\u2009mm), predominantly 5.0\u2009mm, placed in 9247 patients at a single center between January 2014 and December 2023. Implant survival was defined as the fixture remaining in\u00a0situ without clinical loss or replacement at the same site. Failures were classified as early (\u2264\u20091\u2009year) or late (&gt;\u20091\u2009year). Kaplan\u2013Meier survival curves and a multivariable Cox proportional hazards model clustered by patient were generated. Schoenfeld residuals revealed time\u2010varying effects for penicillin allergy, implant length, and kidney disease, prompting a landmark analysis at 365\u2009days with separate multivariable logistic regression models for early and late failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall implant survival was 97.5%. Kaplan\u2013Meier estimates were 98.1% (95% CI: 97.9%\u201398.4%) at 1\u2009year, 97.8% (95% CI: 97.5%\u201398.0%) at 3\u2009years, and 97.6% (95% CI: 97.4%\u201397.9%) at 5\u2009years. Of 301 failures, 225 (74.8%) were early and 76 (25.2%) were late. In the Cox model, short implants (\u2264\u20098\u2009mm; HR\u2009=\u20091.94, 95% CI: 1.43\u20132.62,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), maxillary placement (HR\u2009=\u20092.13 vs. mandible,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), male sex (HR\u2009=\u20091.39,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010), penicillin allergy (HR\u2009=\u20091.66,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014), and older age (HR\u2009=\u20090.84 per SD,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008) independently predicted failure; smoking was borderline (HR\u2009=\u20091.33,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.065). Landmark analysis showed that early failure was driven by penicillin allergy (OR\u2009=\u20092.26,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), maxillary placement (OR\u2009=\u20092.42,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), male sex (OR\u2009=\u20091.40,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016), and short length (OR\u2009=\u20091.70,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007), whereas late failure was driven by short length (OR\u2009=\u20093.19,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and kidney disease (OR\u2009=\u20096.11,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Wide\u2010diameter implants achieve excellent long\u2010term survival. Early and late failures arise from distinct mechanisms: perioperative, anatomical, and sex\u2010related factors predominate early, while short implant length and renal disease predominate late. These findings support tailored perioperative protocols, individualized risk stratification, and targeted long\u2010term surveillance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cid.70173","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:55:28Z","timestamp":1784292928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Failure of Wide\u2010Diameter Dental Implants (Predominantly 5.0\u2009mm) Show Distinct Risk Profiles\u2014A Large Cohort Study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7493-5026","authenticated-orcid":false,"given":"Hadar","family":"Better","sequence":"first","affiliation":[{"name":"MaccabiDent Medical &amp; Quality Assurance Department  Tel Aviv Israel"},{"name":"Research and Innovation Department MaccabiDent  Tel Aviv 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