{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:16:37Z","timestamp":1788513397664,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to compare marginal bone loss (MBL) associated with Hybrid Funnel Technique (HFT) and conventional drill osteotomy for implant site preparation when bioactive implants are used, testing the null hypothesis that no significant differences occur at 1\u2010 and 3\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This prospective non\u2010randomized controlled clinical trial included patients undergoing implant rehabilitation with bioactive\u2010surface implants. Implants were placed using either conventional subtractive drilling (control group) or HFT (test group), which combines selective cortical preparation with medullary osteocompaction. The primary outcome was radiographic MBL at 3\u2010year follow\u2010up. Secondary outcomes included bleeding on probing (BoP) and plaque index (PI). Statistical analyses were performed at implant level, and linear mixed\u2010effects models were used to account for clustering within patients and adjust for potential confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 87 implants in 43 patients were analyzed (42 control, 45 HFT). At 1\u2010year follow\u2010up, the test group reported significantly lower MBL (0.33\u2009\u00b1\u20090.43\u2009mm vs. mean\u2009=\u20090.78\u2009\u00b1\u20090.82\u2009mm; Mann\u2013Whitney\n                      <jats:italic>p<\/jats:italic>\n                      \u2010\n                      <jats:italic>value<\/jats:italic>\n                      \u2009=\u20090.006). At 3\u2009years, MBL was significantly higher in the conventional site preparation group compared with the HFT group (1.34\u2009\u00b1\u20090.79\u2009mm vs. 0.46\u2009\u00b1\u20090.69\u2009mm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In multivariate mixed\u2010effects analysis, the implant site preparation technique was the only variable independently associated with MBL at 3\u2009years (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22121.10\u2009mm, 95% CI\u2009=\u2009\u22121.675 to \u22120.527,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), while insertion torque and other baseline variables showed no significant association. In addition, the HFT group demonstrated significantly lower BoP and PI scores, indicating more favorable peri\u2010implant soft tissue conditions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite the use of identical bioactive\u2010surface\u00a0implants, implant site preparation technique significantly influenced peri\u2010implant bone remodeling. HFT demonstrated superior preservation of marginal bone over 3\u2009years, suggesting that reduction of cortical compression during osteotomy provides a biological advantage. Implant site preparation remains a key determinant of long\u2010term peri\u2010implant bone stability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cid.70175","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:03:42Z","timestamp":1785251022000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hybrid Funnel Technique Reduces Marginal Bone Loss Versus Conventional Drilling: A 3\u2010Year, Prospective, Non\u2010randomized, Controlled Clinical Trial"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9875-2929","authenticated-orcid":false,"given":"Luigi","family":"Canullo","sequence":"first","affiliation":[{"name":"Department of Prosthodontic University of Saint Camillus  Rome Italy"},{"name":"Department of Periodontology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5500-7961","authenticated-orcid":false,"given":"Yaniv","family":"Mayer","sequence":"additional","affiliation":[{"name":"Ruth and Bruce Rappaport Faculty of Medicine at the Technion  Haifa Israel"},{"name":"Department of Periodontology School of Graduate Dentistry, Rambam Health Care Campus  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1562-3660","authenticated-orcid":false,"given":"Federica","family":"Mattalia","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences and Integrated Diagnostics University of Genova  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7171-3491","authenticated-orcid":false,"given":"Iole","family":"D'Urso","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences and Integrated Diagnostics University of Genova  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3746-5675","authenticated-orcid":false,"given":"Filiberto","family":"Mastrangelo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Foggia  Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5080-5921","authenticated-orcid":false,"given":"Vito Carlo Alberto","family":"Caponio","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Health and Health Professions Link Campus University  Rome 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