{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T11:36:09Z","timestamp":1793014569485,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102026\u201025469650"],"award-info":[{"award-number":["RS\u20102026\u201025469650"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to assess the influence of implant timing on peri\u2010implant tissue healing and osseointegration around implants placed in the interradicular septal bone of multirooted teeth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      In seven beagle dogs, the mandibular second and third premolars with bifurcated roots were extracted. Bone\u2010level implants were placed into the septal bone according to four experimental protocols: Immediate (0\u2009week), Early\u20101 (2\u2009weeks), Early\u20102 (4\u2009weeks), and Delayed (8\u2009weeks). All animals were euthanized 16\u2009weeks after tooth extraction. Histomorphometric analysis was performed to assess bone\u2010to\u2010implant contact (BIC), first bone\u2010to\u2010implant contact (fBIC) at the mesial and distal aspects, and peri\u2010implant soft tissue dimensions. Radiographic analysis using micro\u2010computed tomography (micro\u2010CT) was additionally performed to assess fBIC at the buccal and lingual aspects. Statistical analyses were performed using repeated\u2010measures ANOVA for BIC and the Friedman test for fBIC and peri\u2010implant soft tissue parameters, with a significance level set at\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05. Normality and sphericity were confirmed for BIC via Shapiro\u2013Wilk and Mauchly's tests, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Buccal fBIC values gradually decreased with longer healing periods prior to implant placement (Immediate: 3.21\u2009mm; Early\u20101: 2.77\u2009mm; Early\u20102: 2.09\u2009mm; Delayed: 1.82\u2009mm), whereas mesial, distal, and lingual fBIC values were &lt;\u20091\u2009mm in all groups. None of the intergroup differences in fBIC reached statistical significance. BIC values were also comparable among the groups (54.48%, 48.40%, 45.18%, and 54.54%, respectively). Similarly, peri\u2010implant soft tissue measurements, including gingival margin\u2010to\u2010fBIC (3.17\u20134.04\u2009mm) and junctional epithelium\u2010to\u2010fBIC (1.27\u20131.96\u2009mm), did not differ significantly among the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Implant placement performed immediately or at 2, 4, and 8\u2009weeks after tooth extraction without additional bone grafting resulted in successful osseointegration in all groups, with no statistically significant differences in peri\u2010implant tissue healing among the experimental groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cid.70185","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:01:02Z","timestamp":1791504062000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Influence of Implant Timing on Peri\u2010Implant Tissue Healing in Interradicular Septal Bone: A Preclinical in Vivo Study"],"prefix":"10.1111","volume":"28","author":[{"given":"Myong Ji","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Periodontology, Research Institute for Periodontal Regeneration Yonsei University College of Dentistry  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Jin","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Research Institute for Periodontal Regeneration Yonsei University College of Dentistry  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6408-1618","authenticated-orcid":false,"given":"Jin\u2010Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Research Institute for Periodontal Regeneration Yonsei University College of Dentistry  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6906-7209","authenticated-orcid":false,"given":"Jae\u2010Kook","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Research Institute for Periodontal Regeneration Yonsei University College of Dentistry  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6371-4172","authenticated-orcid":false,"given":"Ui\u2010Won","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Research Institute for Periodontal Regeneration Yonsei University College of Dentistry  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1764-7447","authenticated-orcid":false,"given":"Daniel S.","family":"Thoma","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Research Institute for Periodontal Regeneration Yonsei University College of Dentistry  Seoul South Korea"},{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2055-1320","authenticated-orcid":false,"given":"Ronald E.","family":"Jung","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13276"},{"key":"e_1_2_10_3_1","first-page":"26","article-title":"Consensus Statements and Recommended Clinical Procedures Regarding the Placement of Implants in Extraction Sockets","volume":"19","author":"H\u00e4mmerle C. 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