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Interest in these particular adenoviruses is growing in part due to the applications of both in gene transfer protocols, including gene therapy and vaccines, as well in oncolytic protocols. In particular, the re\u2010evaluation of SAdVs as appropriate vectors in humans is important as zoonosis precludes the assumption that human immune system may be na\u00efve to these vectors. Additionally, as important pathogens, adenoviruses are a model organism system for understanding viral pathogen emergence through zoonosis and anthroponosis, particularly among the primate species, along with recombination, host adaptation, and selection, as evidenced by one long\u2010standing human respiratory pathogen HAdV\u20104 and a recent re\u2010evaluation of another, HAdV\u201076. The latter reflects the insights on amphizoonosis, defined as infections in both directions among host species including \u201cother than human\u201d, that are possible with the growing database of nonhuman adenovirus genomes. HAdV\u201076 is a recombinant that has been isolated from human, chimpanzee, and bonobo hosts. On\u2010going and potential impacts of adenoviruses on public health and translational medicine drive this evaluation of 174 whole genome sequences from HAdVs and SAdVs archived in GenBank. The conclusion is that rather than separate HAdV and SAdV phylogenetic lineages, a single, intertwined tree is observed with all HAdVs and SAdVs forming mixed clades. Therefore, a single designation of \u201cprimate adenovirus\u201d (PrAdV) superseding either HAdV and SAdV is proposed, or alternatively, keeping HAdV for human adenovirus but expanding the SAdV nomenclature officially to include host species identification as in ChAdV for chimpanzee adenovirus, GoAdV for gorilla adenovirus, BoAdV for bonobo adenovirus, and <jats:italic>ad libitum<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/cla.12422","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T08:46:43Z","timestamp":1594716403000},"page":"358-373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Genomics\u2010based re\u2010examination of the taxonomy and phylogeny of <i>human<\/i> and <i>simian Mastadenoviruses<\/i>: an evolving whole genomes approach, revealing putative zoonosis, anthroponosis, and amphizoonosis"],"prefix":"10.1111","volume":"36","author":[{"given":"June","family":"Kang","sequence":"first","affiliation":[{"name":"Bioinformatics and Computational Biology Program School of Systems Biology George Mason University Manassas VA 20110 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8694-7235","authenticated-orcid":false,"given":"Ashrafali Mohamed","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Howe Laboratory, Massachusetts Eye and Ear Harvard Medical School Boston MA 02114 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoaleh","family":"Dehghan","sequence":"additional","affiliation":[{"name":"Bioinformatics and Computational Biology Program School of Systems Biology George Mason University Manassas VA 20110 USA"},{"name":"Chemistry Department American University Washington DC 20016 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4559-5613","authenticated-orcid":false,"given":"Jaya","family":"Rajaiya","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Howe Laboratory, Massachusetts Eye and Ear Harvard Medical School Boston MA 02114 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc W.","family":"Allard","sequence":"additional","affiliation":[{"name":"Division of Microbiology (HFS\u2010710) Center for Food Safety &amp; Applied Nutrition, US Food &amp; Drug Administration College Park MD 20740 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haw Chuan","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Biology George Mason University Manassas VA 20110 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W.","family":"Dyer","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University of Oklahoma Health Sciences Center Oklahoma City OK 73104 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7463-1599","authenticated-orcid":false,"given":"James","family":"Chodosh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Howe Laboratory, Massachusetts Eye and Ear Harvard Medical School Boston MA 02114 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0379-0330","authenticated-orcid":false,"given":"Donald","family":"Seto","sequence":"additional","affiliation":[{"name":"Bioinformatics and Computational Biology Program School of Systems Biology George Mason University Manassas VA 20110 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00373-17"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00491-11"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2010.01.011"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2018.00104"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2013.03.014"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/314772"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a121308"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2019.1690953"},{"key":"e_1_2_7_10_1","first-page":"2536","article-title":"Using a pan\u2010viral microarray assay (Virochip) to screen clinical samples for viral pathogens","author":"Chen E.C.","year":"2011","journal-title":"J. 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