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Sockets were either treated with <jats:styled-content style=\"fixed-case\">PRGF<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">PRGF<\/jats:styled-content> group; 18 sites in 11 patients) or left to spontaneous healing (control group; 18 sites in 17 patients). Radiographic and histomorphometric analysis was performed on bone cores trephined from each healing socket after 4\u20136 (T1) or 7\u201310 (T2) weeks of healing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients treated with <jats:styled-content style=\"fixed-case\">PRGF<\/jats:styled-content> application showed (i) similar bone volume and tissue mineral content, (ii) a trend, although not statistically significant, toward a greater number of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>68+ cells (at <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>2) and v<jats:styled-content style=\"fixed-case\">VW<\/jats:styled-content>+ cells (at T1), and (iii) a similar <jats:styled-content style=\"fixed-case\">OCN<\/jats:styled-content> staining score throughout the study, when compared with control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Plasma rich in growth factors\u2010treated group did not show any enhancement in early (4 and 8\u00a0weeks) bone deposition compared with control group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12033","type":"journal-article","created":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T09:47:15Z","timestamp":1348480035000},"page":"1360-1368","source":"Crossref","is-referenced-by-count":39,"title":["Plasma rich in growth factors in human extraction sockets: a radiographic and histomorphometric study on early bone deposition"],"prefix":"10.1111","volume":"24","author":[{"given":"Roberto","family":"Farina","sequence":"first","affiliation":[{"name":"Research Centre for the Study of Periodontal and Peri\u2010Implant Diseases University of Ferrara Ferrara 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