{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:15:36Z","timestamp":1781658936851,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T00:00:00Z","timestamp":1358985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the effect of various systemic antibiotic prophylaxis regimes on patient\u2010reported outcomes and postsurgical complications in patients undergoing conventional implant installation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Three hundred and twenty\u2010nine healthy adults in need of conventional implant installation were randomly assigned to one of four groups: (i) preoperatively 2\u00a0g of amoxycillin 1\u00a0h before surgery (positive control, <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>), (ii) postoperatively 2\u00a0g of amoxycillin immediately following surgery (test 1, T1), (iii) preoperatively 2\u00a0g of amoxycillin 1\u00a0h before and 500\u00a0mg thrice daily on days 2 and 3 after surgery (test 2, T2), (iv) preoperatively 2\u00a0g of placebo 1\u00a0h before surgery (negative control, <jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>). Subjects were examined clinically by blinded examiners over 8\u00a0weeks after implant installation. In addition, Visual Analogue Scales (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>) for pain, swelling, bruising and bleeding were obtained over 14\u00a0days. <jats:styled-content style=\"fixed-case\">ANOVA<\/jats:styled-content> was performed for the <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>. Chi\u2010square tests were applied for postsurgical complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> scores were low for all groups and decreased over time (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). There were no significant differences for the <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> scores between the various groups at any time point (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). There was only a significant difference in flap closure at week 4, where <jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content> had 5% of the subjects not achieving complete wound closure compared to 0% for the three other groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01), with no other significant differences for any postsurgical complications (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For standard single implant placement, prophylactic systemic antibiotics either before or after, or before and after the surgical procedure do not improve patient\u2010reported outcomes or prevalence of postsurgical complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12098","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T15:59:19Z","timestamp":1359043159000},"page":"185-193","source":"Crossref","is-referenced-by-count":59,"title":["Effect of systemic antibiotics on clinical and patient\u2010reported outcomes of implant therapy \u2013 a multicenter randomized controlled clinical trial"],"prefix":"10.1111","volume":"25","author":[{"given":"Wah Ching","family":"Tan","sequence":"first","affiliation":[{"name":"National Dental Centre Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Ong","sequence":"additional","affiliation":[{"name":"National Dental Centre Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Han","sequence":"additional","affiliation":[{"name":"Peking University School of Stomatology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikos","family":"Mattheos","sequence":"additional","affiliation":[{"name":"Griffith University Gold Coast Queensland Australia"},{"name":"Faculty of Dentistry The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjarni E.","family":"Pjetursson","sequence":"additional","affiliation":[{"name":"Faculty of Odontology University of Iceland Reykjavik Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex Yi\u2010Min","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dental Medicine National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Sanz","sequence":"additional","affiliation":[{"name":"Universidad Complutense de Madrid Madrid Spain"},{"name":"ETEP Research Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May C.M.","family":"Wong","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklaus P.","family":"Lang","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on Behalf of the ITI Antibiotic Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.01082.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1998.090202.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01162.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01589.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01645.x"},{"key":"e_1_2_7_7_1","first-page":"283","article-title":"A multicentre placebo\u2010controlled randomised 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