{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:48:31Z","timestamp":1789847311920,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,28]],"date-time":"2013-01-28T00:00:00Z","timestamp":1359331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research Groups","award":["CTS-138"],"award-info":[{"award-number":["CTS-138"]}]},{"name":"Research Groups","award":["CTS-583"],"award-info":[{"award-number":["CTS-583"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Our objectives were to examine vascular and cellular colonization in anorganic bovine bone (<jats:styled-content style=\"fixed-case\">ABB<\/jats:styled-content>) after 6\u00a0months of healing in human maxillary sinus augmentation grafts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Fifty unilateral maxillary sinus augmentation procedures were performed on 50 consecutive patients. Bone cores were obtained through the implant receptor sites 6\u00a0months later and evaluated with morphological image analysis and immunohistochemical techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Image analysis revealed a mean of 35.44\u00a0\u00b1\u00a016% vital bone, 31.66\u00a0\u00b1\u00a015% non\u2010mineralized tissue, and 32.72\u00a0\u00b1\u00a025% remnant <jats:styled-content style=\"fixed-case\">ABB<\/jats:styled-content> particles. In our patients, neovascularization in 46.3% of cases was demonstrated within <jats:styled-content style=\"fixed-case\">ABB<\/jats:styled-content> particles 6\u00a0months after sinus floor augmentation surgery. Neovascularization of <jats:styled-content style=\"fixed-case\">ABB<\/jats:styled-content> particles was inversely related to age, directly to osteoclast number per mm\u00b2, and not influenced by habits or disease. <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>44\u2010positive cells colonization was found in 74% of cases. An important correlation was found regarding <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>44 expression and number of vessel in <jats:styled-content style=\"fixed-case\">ABB<\/jats:styled-content> particles (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.624 <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001, Pearson). Osteopontin expression was detected on the interstitial boundary of bone with <jats:styled-content style=\"fixed-case\">ABB<\/jats:styled-content> particles and within the osteocyte lacunae and bone canaliculi and was relationship with presence of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>44\u2010positive cells inside <jats:styled-content style=\"fixed-case\">ABB<\/jats:styled-content> particles (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.388, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.046, Pearson).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, images compatible with osteone colonized by osteocytes <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>44 positive and neovascularization in <jats:styled-content style=\"fixed-case\">ABB<\/jats:styled-content> particles were observed after 6\u00a0months of graft maturation. These biologic events have not previously been morphologically and immunohistochemically documented.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12112","type":"journal-article","created":{"date-parts":[[2013,1,29]],"date-time":"2013-01-29T01:39:06Z","timestamp":1359423546000},"page":"366-371","source":"Crossref","is-referenced-by-count":29,"title":["Morphological evidences of <scp>B<\/scp>io\u2010<scp>O<\/scp>ss<sup>\u00ae<\/sup> colonization by <scp>CD<\/scp>44\u2010positive cells"],"prefix":"10.1111","volume":"25","author":[{"given":"Pablo","family":"Galindo\u2010Moreno","sequence":"first","affiliation":[{"name":"Oral Surgery and Implant Dentistry Department School of Dentistry University of Granada Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Hern\u00e1ndez\u2010Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Orthopedic Surgery San Cecilio Clinical Hospital University of Granada Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Aneiros\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"San Cecilio Clinical Hospital University of Granada University of Granada Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Camara","sequence":"additional","affiliation":[{"name":"San Cecilio Clinical Hospital University of Granada University of Granada Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Mesa","sequence":"additional","affiliation":[{"name":"Periodontology Department School of Dentistry University of Granada Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Periodontology Columbia University New York NY 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