{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:09:37Z","timestamp":1790885377529,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T00:00:00Z","timestamp":1360713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>A prospective double\u2010blind randomised controlled trial was conducted to test the effect of prophylactic antibiotics on post\u2010operative morbidity and osseointegration of dental implants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Fifty\u2010five subjects scheduled for implant surgery were enrolled. The patients were randomly assigned to the antibiotic (test group) and placebo (control group). Twenty\u2010seven patients (test group) received 3\u00a0g amoxicillin one hour pre\u2010operatively, and 28 patients (control group) received placebo capsules 1\u00a0h pre\u2010operatively. No post\u2010operative antibiotics were prescribed. Pain diaries and interference with daily activities diaries were kept by the patients for 1\u00a0week post\u2010operatively. Signs of post\u2010operative morbidity (swelling, bruising, suppuration and wound dehiscence) were recorded by the principal investigators at day 2 and day 7 following the operation. Osseointegration was assessed at 2nd stage surgery or 3\u20134\u00a0months post\u2010operatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results of this study suggest that the use of prophylactic pre\u2010operative antibiotics may result in higher dental implant survival rates (100% vs. 82%). Five implant failures, one in each of five patients, were reported in the placebo group and none in the antibiotic group (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0515). No significant differences were found for most of the signs of post\u2010operative morbidity 2 and 7\u00a0days post\u2010operatively. Only bruising at 2\u00a0days following the operation appeared to be higher in the placebo group (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0511). Post\u2010operative pain (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.01) and interference with daily activities (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.01) appeared to be significantly lower for the antibiotic group after 7\u00a0days. Those patients with implant failure reported higher pain (based on the VAS scores) after 2\u00a0days (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.003) and after 7\u00a0days (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0005), higher pain (based on the amount of analgesics used) after 7\u00a0days (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.001) and higher interference with daily activities (based on the VAS scores) after 2\u00a0days (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of for dental implant surgery may be justified, as it appears to improve implant survival in the short term and also results in less post\u2010operative pain and interference with daily activities. From the results of this study, it appears that prophylactic antibiotics may also be beneficial both in terms of implant survival, especially when the surgical procedure is prolonged due to its difficulty, high number of implants placed or operator's inexperience.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12124","type":"journal-article","created":{"date-parts":[[2013,2,14]],"date-time":"2013-02-14T04:19:04Z","timestamp":1360815544000},"page":"252-259","source":"Crossref","is-referenced-by-count":61,"title":["The influence of prophylactic antibiotic administration on post\u2010operative morbidity in dental implant surgery. 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