{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:44:12Z","timestamp":1789803852253,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T00:00:00Z","timestamp":1361750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the clinical and histological outcomes of a resorbable modified polylactide\/polyglycolide acid (PLGA) test membrane and a titanium\u2010reinforced expanded polytetrafluorethylene (ePTFE) control membrane used for guided bone regeneration (GBR) around dental implants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A total of 40 patients with peri\u2010implant dehiscence\u2010type defects were randomly allocated to a GBR procedure using either a modified PLGA test or an ePTFE control membrane. Soft tissue condition, implant integration, adverse events and quality of life were recorded during the 6\u2010month healing period. At re\u2010entry peri\u2010implant bone defect dimensions were measured and compared with values recorded at implant\/GBR surgery. A biopsy was retrieved for qualitative and quantitative histological analyses. A comparison between the groups was conducted using non\u2010parametric statistical tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Soft tissue complications were observed in five test patients and two control patients. Except for soft tissue complications and incomplete regeneration, no procedure\u2010 or device\u2010related adverse events were observed. The vertical bone defect component was, in mean, reduced by\u22125.1\u00a0mm (95% CI \u22126.8, \u22123.3) in the test group and \u22126.9\u00a0mm (95% CI \u22128.2, \u22125.5\u00a0mm) in the control group. The mean residual vertical defect height measured 1.2\u00a0\u00b1\u00a02.4\u00a0mm in the test group and 0.3\u00a0\u00b1\u00a01.1\u00a0mm in the control group meaning a mean defect resolution of 81% in the test group and 96% in the control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.161). The horizontal bone thickness at implant shoulder level decreased from a mean of 3.2\u00a0mm to 1.4\u00a0mm (\u221256%, mean \u22121.7\u00a0mm, 95% CI \u22122.3, \u22121.1) in the test group and from 3.3\u00a0mm to 2.5\u00a0mm (\u221224%, mean \u22120.8\u00a0mm, 95% CI \u22121.3, \u22120.3) in the control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.022). Qualitative and quantitative histological analyses did not show significant differences in the tissue composition between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Peri\u2010implant GBR was successfully performed using either of the membranes. The control membrane was able to better maintain the horizontal thickness of regenerated bone and revealed less soft tissue complications. No statistically valid evidence about the superiority of one membrane was found in any other parameters. Soft tissue dehiscences occur with both types of membranes and can impair the amount of regenerated bone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12132","type":"journal-article","created":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T07:47:48Z","timestamp":1361778468000},"page":"150-158","source":"Crossref","is-referenced-by-count":59,"title":["A randomized controlled clinical multicenter trial comparing the clinical and histological performance of a new, modified polylactide\u2010co\u2010glycolide acid membrane to an expanded polytetrafluorethylene membrane in guided bone regeneration procedures"],"prefix":"10.1111","volume":"25","author":[{"given":"David","family":"Schneider","sequence":"first","affiliation":[{"name":"Clinic for Fixed and Removable Prosthodontics and Dental Material Science University of Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz E.","family":"Weber","sequence":"additional","affiliation":[{"name":"Division of Cranio\u2010Maxillofacial and Oral Surgery, Section Oral Biotechnology &amp; Bioengineering University Hospital Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ueli","family":"Grunder","sequence":"additional","affiliation":[{"name":"Private Practice Zollikon Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Andreoni","sequence":"additional","affiliation":[{"name":"Private Practice Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rino","family":"Burkhardt","sequence":"additional","affiliation":[{"name":"Private Practice Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald E.","family":"Jung","sequence":"additional","affiliation":[{"name":"Clinic for Fixed and Removable Prosthodontics and Dental Material Science University of Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,25]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"843","article-title":"Membrane durability and tissue response of different bioresorbable barrier membranes: a histologic study in the rabbit calvarium","volume":"20","author":"Arx T.","year":"2005","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1054\/ijom.2001.0205"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2005.01106.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ID.0000127520.06443.42"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.11.1743"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01781.x"},{"key":"e_1_2_7_8_1","first-page":"273","article-title":"Membrane\u2010induced bone augmentation at titanium implants. A report on ten fixtures followed from 1 to 3\u00a0years after loading","volume":"11","author":"Dahlin C.","year":"1991","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1998.090205.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2005.01154.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1982.tb00172.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.11.1616"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.223297"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1998.tb00132.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1996.070105.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00161.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01634.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.02068.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.4.512"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2009.0009"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2006.01.030"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1994.tb00011.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(96)00049-4"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1997.080503.x"},{"key":"e_1_2_7_25_1","first-page":"166","article-title":"A comparative study of the effectiveness of e\u2010ptfe membranes with and without early exposure during the healing period","volume":"14","author":"Simion M.","year":"1994","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_7_26_1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0011-8532(22)02425-9","article-title":"Right\u2010angle dental radiography","author":"Updegrave W.J.","year":"1968","journal-title":"Dental Clinics of North America"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.150.3698.893"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199801000-00006"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3201241"},{"key":"e_1_2_7_30_1","first-page":"844","article-title":"Resorbable versus nonresorbable membranes in combination with bio\u2010oss for guided bone regeneration","volume":"12","author":"Zitzmann N.U.","year":"1997","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01751.x"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fclr.12132","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.12132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T05:06:26Z","timestamp":1696309586000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/clr.12132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,25]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/clr.12132"],"URL":"https:\/\/doi.org\/10.1111\/clr.12132","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,25]]}}}