{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:56:08Z","timestamp":1787759768500,"version":"build-2784847793"},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T00:00:00Z","timestamp":1361923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Regulators of peri\u2010implant bone loss in patients with diabetes appear to involve multiple risk factors that have not been clearly elucidated. This study was conducted to explore putative local etiologic factors on implant bone loss in relation to type 2 diabetes mellitus, including clinical, microbial, salivary biomarker, and psychosocial factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Thirty\u2010two subjects (divided into type 2 diabetes mellitus and non\u2010diabetic controls), having at least one functional implant and six teeth, were enrolled in a 1\u2010year longitudinal investigation. Analyses of clinical measurements and standardized intra\u2010oral radiographs, saliva and serum biomarkers (via protein arrays for 20 selected markers), and plaque biofilm (via q<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> for eight periodontal pathogens) were performed at baseline and 1\u00a0year. In addition, the subjects were asked to respond to questionnaires to assess behavioral and psychosocial variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant increase from baseline to 1\u00a0year in the probing depth of implants in the diabetes group (1.95\u00a0mm to 2.35\u00a0mm, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.015). The average radiographic bone loss during the study period marginally increased at dental implants compared to natural teeth over the study period (0.08\u00a0mm vs. 0.05\u00a0mm; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.043). The control group harbored higher levels of <jats:italic><jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reponema denticola<\/jats:italic> at their teeth at baseline (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.046), and the levels of the pathogen increased significantly over time around the implants of the same group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003). Salivary osteoprotegerin (<jats:styled-content style=\"fixed-case\">OPG<\/jats:styled-content>) levels were higher in the diabetes group than the control group at baseline only; in addition, the salivary levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010, and <jats:styled-content style=\"fixed-case\">OPG<\/jats:styled-content> associated with host defense were significantly reduced in the diabetes group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.010, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.019, and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.024), while controls showed an increase in the salivary <jats:styled-content style=\"fixed-case\">OPG<\/jats:styled-content> levels (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005). For psychosocial factors, there were not many significant changes over the observation period, except for some findings related to coping behaviors at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study suggests that the clinical, microbiological, salivary biomarker, and psychosocial profiles of dental implant patients with type 2 diabetes who are under good metabolic control and regular maintenance care are very similar to those of non\u2010diabetic individuals. Future studies are warranted to validate the findings in longer\u2010term and larger clinical trials (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link> # NCT00933491).<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12139","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T13:15:06Z","timestamp":1361970906000},"page":"803-812","source":"Crossref","is-referenced-by-count":37,"title":["Clinical, microbiological, and salivary biomarker profiles of dental implant patients with type 2 diabetes"],"prefix":"10.1111","volume":"25","author":[{"given":"Nikolaos","family":"Tatarakis","sequence":"first","affiliation":[{"name":"Department of Periodontics and Oral Medicine Michigan Center for Oral Health Research University of Michigan School of Dentistry Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet 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