{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:40:39Z","timestamp":1788871239872,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T00:00:00Z","timestamp":1365379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Bredent Medical GmbH & Co. KG, Gesch\u00e4ftsbereich HELBO"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2014,3]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n \n The objective of the study is to compare the clinical, microbiological and host\u2010derived effects in the non\u2010surgical treatment of initial peri\u2010implantitis with either adjunctive local drug delivery (\n LDD<\/jats:styled-content>\n ) or adjunctive photodynamic therapy (\n PDT<\/jats:styled-content>\n ) after 12\u00a0months.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n Forty subjects with initial peri\u2010implantitis, that is, pocket probing depths (\n PPD<\/jats:styled-content>\n ) 4\u20136\u00a0mm with bleeding on probing (BoP) and radiographic bone loss \u22642\u00a0mm, were randomly assigned to two treatment groups. All implants were mechanically debrided with titanium curettes and with a glycine\u2010based powder airpolishing system. Implants in the test group (\n N<\/jats:italic>\n \u00a0=\u00a020) received adjunctive\n PDT<\/jats:styled-content>\n , whereas minocycline microspheres were locally delivered into the peri\u2010implant pockets of control implants (\n N<\/jats:italic>\n \u00a0=\u00a020). At sites with residual BoP, treatment was repeated after 3, 6, 9 and 12\u00a0months. The primary outcome variable was the change in the number of peri\u2010implant sites with BoP. Secondary outcome variables included changes in\n PPD<\/jats:styled-content>\n , clinical attachment level (\n CAL<\/jats:styled-content>\n ), mucosal recession (\n REC<\/jats:styled-content>\n ) and in bacterial counts and crevicular fluid (\n CF<\/jats:styled-content>\n ) levels of host\u2010derived biomarkers.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n After 12\u00a0months, the number of BoP\u2010positive sites decreased statistically significantly (\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.05) from baseline in both groups (\n PDT<\/jats:styled-content>\n : 4.03\u00a0\u00b1\u00a01.66\u20131.74\u00a0\u00b1\u00a01.37,\n LDD<\/jats:styled-content>\n : 4.41\u00a0\u00b1\u00a01.47\u20131.55\u00a0\u00b1\u00a01.26). A statistically significant (\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.05) decrease in\n PPD<\/jats:styled-content>\n from baseline was observed at\n PDT<\/jats:styled-content>\n \u2010treated sites up to 9\u00a0months (4.19\u00a0\u00b1\u00a00.55\u00a0mm to 3.89\u00a0\u00b1\u00a00.68\u00a0mm) and up to 12\u00a0months at\n LDD<\/jats:styled-content>\n \u2010treated sites (4.39\u00a0\u00b1\u00a00.77\u00a0mm to 3.83\u00a0\u00b1\u00a00.85\u00a0mm). Counts of\n Porphyromonas gingivalis<\/jats:italic>\n and\n Tannerella forsythia<\/jats:italic>\n decreased statistically significantly (\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.05) from baseline to 6\u00a0months in the\n PDT<\/jats:styled-content>\n and to 12\u00a0months in the\n LDD<\/jats:styled-content>\n group, respectively.\n CF<\/jats:styled-content>\n levels of\n IL<\/jats:styled-content>\n \u20101\u03b2 decreased statistically significantly (\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.05) from baseline to 12\u00a0months in both groups. No statistically significant differences (\n P\u00a0<\/jats:italic>\n >\n \u00a0<\/jats:italic>\n 0.05) were observed between groups after 12\u00a0months with respect to clinical, microbiological and host\u2010derived parameters.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Non\u2010surgical mechanical debridement with adjunctive\n PDT<\/jats:styled-content>\n was equally effective in the reduction of mucosal inflammation as with adjunctive delivery of minocycline microspheres up to 12\u00a0months. Adjunctive\n PDT<\/jats:styled-content>\n may represent an alternative approach to\n LDD<\/jats:styled-content>\n in the non\u2010surgical treatment of initial peri\u2010implantitis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/clr.12155","type":"journal-article","created":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T03:59:55Z","timestamp":1365393595000},"page":"279-287","source":"Crossref","is-referenced-by-count":213,"title":["Anti\u2010infective therapy of peri\u2010implantitis with adjunctive local drug delivery or photodynamic therapy: 12\u2010month outcomes of a randomized controlled clinical trial"],"prefix":"10.1111","volume":"25","author":[{"given":"Mario","family":"Bassetti","sequence":"first","affiliation":[{"name":"Department of Periodontology School of Dental Medicine University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothee","family":"Sch\u00e4r","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dental Medicine University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat","family":"Wicki","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dental Medicine University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrun","family":"Eick","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dental Medicine University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph A.","family":"Ramseier","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dental Medicine University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole B.","family":"Arweiler","sequence":"additional","affiliation":[{"name":"Department of Periodontology Philipps University Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dental Medicine University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni E.","family":"Salvi","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dental Medicine University of Bern Bern 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