{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:11:04Z","timestamp":1789495864417,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T00:00:00Z","timestamp":1369267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Aim of the pilot trial was to evaluate applicability and effects of directly autotransplanted tibial bone marrow (<jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content>) aspirates on the incorporation of porous bovine bone mineral in a sinus lift model and on the osseointegration of dental implants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Six edentulous patients with bilaterally severely resorbed maxillae requiring sinus augmentation and implant treatment were included. During surgery, tibial <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> was harvested and added to bone substitute material (Bio\u2010Oss<jats:sup>\u00ae<\/jats:sup>) at the randomly selected test site. At control sites, augmentation was performed with Bio\u2010Oss<jats:sup>\u00ae<\/jats:sup> alone. The cellular content of each <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> aspirate was checked for multipotency and surface antigen expression as quality control. Histomorphometric analysis of biopsies from the augmented sites after 3 and 6\u00a0months (during implantation) was used to evaluate effects on bone regeneration. Osseointegration of implants was evaluated with Periotest<jats:sup>\u00ae<\/jats:sup> and radiographic means.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multipotent cellular content in tibial <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> aspirates was comparable to that in punctures from the iliac crest. No significant difference in amount of new bone formation and the integration of bone substitute particles was detected histomorphometrically. Periotest<jats:sup>\u00ae<\/jats:sup> values and radiographs showed successful osseointegration of inserted implants at all sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Directly autotransplanted tibial <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> aspirates did not show beneficial regenerative effects in the small study population (<jats:italic>N<\/jats:italic>\u00a0=\u00a06) of the present pilot trial. However, the proximal tibia proved to be a potential donor site for small quantities of <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content>. Future trials should clarify whether concentration of tibial <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> aspirates could effect higher regenerative potency.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12172","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T13:22:52Z","timestamp":1369315372000},"page":"468-474","source":"Crossref","is-referenced-by-count":24,"title":["Effects of directly autotransplanted tibial bone marrow aspirates on bone regeneration and osseointegration of dental implants"],"prefix":"10.1111","volume":"25","author":[{"given":"Michael","family":"Payer","sequence":"first","affiliation":[{"name":"Department of Oral Surgery and Radiology School of Dentistry Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Lohberger","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Medical University of Graz Graz 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