{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:03:20Z","timestamp":1790442200195,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T00:00:00Z","timestamp":1366070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this pilot study was to evaluate the vertical osteoconductive and osteointegrative dynamics around titanium\u2013zirconium (TiZr) implants compared to titanium (Ti) implants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>In a split\u2010leg design, 12 TiZr\u2010SLActive and 12 Ti\u2010SLActive implants were inserted 3\u00a0mm above bone level in the proximal tibia of 12 rabbits. Full periosteal flaps were repositioned to cover the site. Specimens were obtained after 10, 20 and 30\u00a0days (each <jats:italic>n\u00a0<\/jats:italic>=\u00a04 per group). Histomorphometric measurements included percentage of linear bone fill (PLF; %), new marginal vertical bone height (VBH; mm) and vertical bone\u2010to\u2010implant contact (<jats:styled-content style=\"fixed-case\">vBIC<\/jats:styled-content>; %). Statistical analysis was performed with the nonparametric F1_LD_F1 model to compare the two groups at the different time points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 10\u00a0days, mean PLF was 7.7% (standard deviation (SD): 5.3) for TiZr and 17.6 (SD: 8.3) for Ti. Mean VBH was 0.35\u00a0mm (SD: 0.15) and 0.78\u00a0mm (SD: 0.4) for TiZr and Ti, respectively; mean <jats:styled-content style=\"fixed-case\">vBIC<\/jats:styled-content> was 24.4% (SD: 41) for TiZr and 53% (SD: 28.9) for Ti samples. The differences were significant for all parameters (PLF: <jats:italic>P\u00a0<\/jats:italic>=\u00a00.021; VBH: <jats:italic>P\u00a0<\/jats:italic>=\u00a00.009; <jats:styled-content style=\"fixed-case\">vBIC<\/jats:styled-content>:<jats:italic> P\u00a0<\/jats:italic>=\u00a00.011). After 20\u00a0days, mean PLF was 44.3% (SD: 26.3) for TIZr and 46.2% (SD: 21.3) for Ti implants. TiZr showed a mean VBH of 1.73\u00a0mm (SD: 1) and 1.8\u00a0mm (SD: 0.6) for Ti samples. Mean <jats:styled-content style=\"fixed-case\">vBIC<\/jats:styled-content> had values of 48.3% (SD: 23.7) and 68.7% (SD: 35.5) for TiZr and Ti, respectively (PLF: <jats:italic>P\u00a0<\/jats:italic>=\u00a00.78; VBH: <jats:italic>P\u00a0<\/jats:italic>=\u00a00.58; <jats:styled-content style=\"fixed-case\">vBIC<\/jats:styled-content>:<jats:italic> P\u00a0<\/jats:italic>=\u00a00.47). At the point of 30\u00a0days, mean PLF values were 23.7% (SD: 3.8) for TiZr and 28.9% (SD: 21.7) for Ti samples; mean for VBH in TiZr samples was 0.65\u00a0mm (SD: 0.39) and 1.7\u00a0mm (SD: 1.1) for Ti ones. Finally, mean <jats:styled-content style=\"fixed-case\">vBIC<\/jats:styled-content> was 28.3% (SD: 19.3) and 54.4% (SD: 26.5) for TiZr and Ti samples, respectively (PLF: <jats:italic>P\u00a0<\/jats:italic>=\u00a00.1; VBH: <jats:italic>P\u00a0<\/jats:italic>=\u00a00.088; <jats:styled-content style=\"fixed-case\">vBIC<\/jats:styled-content>:<jats:italic> P\u00a0<\/jats:italic>=\u00a00.089).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A significant delay in vertical osteoconductivity at the earliest time point under examination was seen for TiZr implants when compared to their Ti counterparts. For the later points, TiZr as well as Ti implants demonstrated comparable values in this animal model. The long\u2010term osteogenic surface properties of equally pretreated TiZr dental implants are therefore similar to those of Ti implants <jats:italic>in vivo<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12175","type":"journal-article","created":{"date-parts":[[2013,4,17]],"date-time":"2013-04-17T03:35:23Z","timestamp":1366169723000},"page":"774-780","source":"Crossref","is-referenced-by-count":24,"title":["Vertical osteoconductivity and early bone formation of titanium\u2013zirconium and titanium implants in a subperiosteal rabbit animal model"],"prefix":"10.1111","volume":"25","author":[{"given":"Peer W.","family":"K\u00e4mmerer","sequence":"first","affiliation":[{"name":"Department of Oral Maxillofacial and Plastic Surgery University Medical Centre Mainz Mainz Germany"},{"name":"Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Palarie","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University of Chisinau Chisinau Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eik","family":"Schiegnitz","sequence":"additional","affiliation":[{"name":"Department of Oral Maxillofacial and Plastic Surgery University Medical Centre Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Hagmann","sequence":"additional","affiliation":[{"name":"Department of Orthopedics University of Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulmonem","family":"Alshihri","sequence":"additional","affiliation":[{"name":"Department of Restorative and Biomaterial Sciences Harvard School of Dental Medicine Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal","family":"Al\u2010Nawas","sequence":"additional","affiliation":[{"name":"Department of Oral Maxillofacial and Plastic Surgery University Medical Centre Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2007.01395.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2010.00324.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2009.00237.x"},{"key":"e_1_2_7_5_1","first-page":"1309","article-title":"Retrospective clinical evaluation of an internal tube\u2010in\u2010tube dental implant after 4\u00a0years, with special emphasis on peri\u2010implant bone resorption","volume":"26","author":"Al\u2010Nawas B.","year":"2011","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02231.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2003.00972.x"},{"key":"e_1_2_7_8_1","first-page":"659","article-title":"Early loading of nonsubmerged titanium implants with a sandblasted and acid\u2010etched (SLA) surface: 3\u2010year results of a prospective study in partially edentulous patients","volume":"18","author":"Bornstein M.M.","year":"2003","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2007.01473.x"},{"key":"e_1_2_7_10_1","volume-title":"Nonparametric Analysis of Longitudinal Data in Factorial Experiments","author":"Brunner E.","year":"2002"},{"key":"e_1_2_7_11_1","first-page":"761","article-title":"Implants in the atrophic partially edentulous maxilla. 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