{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:59:02Z","timestamp":1770749942089,"version":"3.50.0"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,7,4]],"date-time":"2013-07-04T00:00:00Z","timestamp":1372896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the impact of a cross\u2010linked\u2010 (<jats:styled-content style=\"fixed-case\">VN<\/jats:styled-content>) collagen membrane on the long\u2010term stability of peri\u2010implant health over 6\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Vestibular dehiscence\u2010type defects at titanium implants (19 patients, 19 implants) were augmented using a natural bone mineral and randomly allocated to either <jats:styled-content style=\"fixed-case\">VN<\/jats:styled-content> or a native collagen membrane (<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>) and left to heal in a submerged position for 4\u00a0months. Clinical parameters (i.e. Bleeding on Probing\u2010<jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content>, probing pocket depth\u2010<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>, mucosal recession\u2010<jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>) were recorded at 4 and 6\u00a0years after prosthesis installation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 4 and 6\u00a0years, both <jats:styled-content style=\"fixed-case\">VN<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> revealed comparable mean <jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> PD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> values at both vestibular and oral aspects. Changes in these parameters from 4 to 6\u00a0years were minimal (vestibular aspect\u2010<jats:styled-content style=\"fixed-case\">VN<\/jats:styled-content>: \u22123.3\u00a0\u00b1\u00a048.2%, \u22120.1\u00a0\u00b1\u00a00.5\u00a0mm, \u22120.1\u00a0\u00b1\u00a00.3\u00a0mm; <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>: \u22121.8\u00a0\u00b1\u00a033.7%, 0.0\u00a0\u00b1\u00a00.4\u00a0mm, \u22120.1\u00a0\u00b1\u00a00.7\u00a0mm) and not significantly different between groups. At 6\u00a0years, the incidence of mucositis and peri\u2010implantitis was comparable in both groups (<jats:styled-content style=\"fixed-case\">VN<\/jats:styled-content>: 60.0% and 20.0%; <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>: 33.3% and 33.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, the present follow\u2010up observation failed to identify any beneficial impact of <jats:styled-content style=\"fixed-case\">VN<\/jats:styled-content> over <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> on peri\u2010implant health at 4 and 6\u00a0years.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12220","type":"journal-article","created":{"date-parts":[[2013,7,4]],"date-time":"2013-07-04T10:41:12Z","timestamp":1372934472000},"page":"1010-1015","source":"Crossref","is-referenced-by-count":22,"title":["Long\u2010term follow\u2010up of simultaneous guided bone regeneration using native and cross\u2010linked 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