{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:25:32Z","timestamp":1770884732365,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T00:00:00Z","timestamp":1372723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To address the criticisms raised by Anitua et\u00a0al. (<jats:italic>European Journal of Oral Implantology<\/jats:italic>, 6, 2013, 9\u201311) to the article \u201c<jats:italic>Plasma Rich in Growth Factors (<jats:styled-content style=\"fixed-case\">PRGF<\/jats:styled-content>) in Human Post\u2010Extraction Sockets: an Histological and Histomorphometric Study<\/jats:italic>.\u201d, recently published by Farina and colleagues (<jats:italic>Clinical Oral Implants Research<\/jats:italic>2012; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1111\/clr.12033\">10.1111\/clr.12033<\/jats:ext-link>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All the methodological aspects criticized in the letter by Anitua et\u00a0al. were thoroughly reconsidered and discussed in a structured short communication. When indicated, pertinent, additional material was included to reinforce our considerations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As most clinical studies in implant dentistry, including previous studies evaluating the efficacy\/effectiveness of<jats:styled-content style=\"fixed-case\">PRGF<\/jats:styled-content>, the study by Farina et\u00a0al. has some limitations. However, it is currently the only published controlled trial using quantitative parameters related to<jats:styled-content style=\"fixed-case\">PRGF<\/jats:styled-content>\u2010induced early bone formation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite all limitations, the results of the study by Farina et\u00a0al., which were based on different quantitative parameters (micro\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>scan, immunohistochemical markers of wound healing and bone deposition), indicated a limited effect of<jats:styled-content style=\"fixed-case\">PRGF<\/jats:styled-content>on early bone formation in extraction sockets.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12230","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T07:14:20Z","timestamp":1372749260000},"page":"1189-1191","source":"Crossref","is-referenced-by-count":2,"title":["Plasma rich in growth factors had limited effect on early bone formation in extraction sockets"],"prefix":"10.1111","volume":"25","author":[{"given":"Roberto","family":"Farina","sequence":"first","affiliation":[{"name":"Research Centre for the Study of Periodontal and Peri\u2010Implant Diseases University of Ferrara Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eriberto","family":"Bressan","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Specialties University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Taut","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine School of Dentistry University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Cucchi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Ferrara Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Trombelli","sequence":"additional","affiliation":[{"name":"Research Centre for the Study of Periodontal and Peri\u2010Implant Diseases University of Ferrara Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,2]]},"reference":[{"key":"e_1_2_2_2_1","first-page":"1133","article-title":"Bone tissue formation in extraction sockets from sites with advanced periodontal disease: a histomorphometric study in humans","volume":"23","author":"Ahn J.J.","year":"2008","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_2_3_1","first-page":"529","article-title":"Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants","volume":"14","author":"Anitua E.","year":"1999","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_2_4_1","first-page":"9","article-title":"Letter to the Editor: rigorous methodology is the school of coherent conclusions in science","volume":"6","author":"Anitua E.","year":"2013","journal-title":"European Journal of Oral Implantology"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01839.x"},{"key":"e_1_2_2_6_1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/jbm.b.31631","article-title":"Functional apparent moduli as predictors of oral implant osseointegration dynamics","volume":"94","author":"Chang P.C.","year":"2010","journal-title":"Journal of Biomedical Materials Research. 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(2013) Letter to the Editor: Rigorous methodology is the school of coherent conclusions in science.<i>European Journal of Oral Implantology<\/i><b>6<\/b>: 9\u201311.\u201d"],"short-title":[],"issued":{"date-parts":[[2013,7,2]]},"references-count":21,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/clr.12230"],"URL":"https:\/\/doi.org\/10.1111\/clr.12230","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,2]]}}}