{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:52:35Z","timestamp":1740124355589,"version":"3.37.3"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T00:00:00Z","timestamp":1379548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>It is supposed that the demographic change will lead to an increase in patients with impaired alveolar bone conditions. Large animal models are of particular interest in this context as they are suitable for developing and testing new dental implants. Recently, we demonstrated that surgical hypothalamo\u2013pituitary disconnection (<jats:styled-content style=\"fixed-case\">HPD<\/jats:styled-content>) causes a pronounced low\u2010turnover situation leading to cortical and trabecular bone loss in sheep. In this study, we aimed to investigate the influence of the <jats:styled-content style=\"fixed-case\">HPD<\/jats:styled-content> procedure on the alveolar bone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten adult Merino ewes were randomly assigned to two groups: <jats:italic>Control<\/jats:italic> and <jats:italic>HPD<\/jats:italic>. After 6\u00a0months, we analysed the cortical and trabecular bone of all mandibles by histomorphometry and high\u2010resolution peripheral quantitative computed tomography (HR\u2010<jats:styled-content style=\"fixed-case\">pQCT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>HPD<\/jats:italic> ewes showed a significant decrease in cortical thickness by ~20%, a significant increase in cortical porosity by ~20% and a significant decrease in bone volume by ~30% in comparison with <jats:italic>Control<\/jats:italic> ewes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results underline the importance of central regulatory mechanisms of bone turnover. However, further studies are needed to understand these central regulatory elements of bone turnover in detail and to judge the value of the <jats:styled-content style=\"fixed-case\">HPD<\/jats:styled-content> sheep for dental research.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12259","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T15:15:23Z","timestamp":1381245323000},"page":"1239-1244","source":"Crossref","is-referenced-by-count":3,"title":["Mandibular bone loss in ewe induced by hypothalamic\u2013pituitary disconnection"],"prefix":"10.1111","volume":"25","author":[{"given":"Ralf","family":"Oheim","sequence":"first","affiliation":[{"name":"Department of Osteology and Biomechanics University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. 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