{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:03:41Z","timestamp":1790442221940,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,9,18]],"date-time":"2013-09-18T00:00:00Z","timestamp":1379462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Institut Straumann"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the suitability of a minipig model for the study of bone healing and osseointegration of dental implants following bone splitting and expansion of narrow ridges.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>In four minipigs, the mandibular premolars and first molars were extracted together with removal of the buccal bone plate. Three months later, ridge splitting and expansion was performed with simultaneous placement of three titanium implants per quadrant. On one side of the mandible, the expanded bone gap between the implants was filled with an alloplastic biphasic calcium phosphate (<jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content>) material, while the gap on the other side was left unfilled. A barrier membrane was placed in half of the quadrants. After a healing period of 6\u00a0weeks, the animals were sacrificed for histological evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all groups, no bone fractures occurred, no implants were lost, all 24 implants were osseointegrated, and the gap created by bone splitting was filled with new bone, irrespective of whether <jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content> or a barrier membrane was used. Slight exposure of five implants was observed, but did not lead to implant loss. The level of the most coronal bone\u2010to\u2010implant contact varied without being dependent on the use of <jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content> or a barrier membrane. In all groups, the <jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content> particles were not present deep in the bone\u2010filled gap. However, <jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content> particles were seen at the crestal bone margin, where they were partly integrated in the new bone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This new minipig model holds great promise for studying experimental ridge splitting\/expansion. However, efforts must be undertaken to reduce implant exposure and buccal bone resorption.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12265","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T14:29:56Z","timestamp":1381242596000},"page":"1265-1272","source":"Crossref","is-referenced-by-count":21,"title":["Evaluation of a new experimental model to study bone healing after ridge expansion with simultaneous implant placement \u2013 a pilot study in minipigs"],"prefix":"10.1111","volume":"25","author":[{"given":"Andres","family":"Stricker","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Fleiner","sequence":"additional","affiliation":[{"name":"Oral Imaging Center Faculty of Medicine Katholieke Universiteit Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Dard","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implant Dentistry New York University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pit","family":"Voss","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Sauerbier","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter D.","family":"Bosshardt","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Stomatology School of Dental Medicine University of Bern Bern Switzerland"},{"name":"Department of Periodontology School of Dental Medicine University of Bern Bern Switzerland"},{"name":"Robert K. 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