{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T02:51:36Z","timestamp":1774493496012,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T00:00:00Z","timestamp":1381190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to present the 10\u2010year clinical and radiographic data from a <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content> on single\u2010tooth implants placed early, delayed, or late after tooth extraction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Sixty\u2010three patients were randomly allocated to three groups and received an implant on average 10\u00a0days (<jats:styled-content style=\"fixed-case\">Ea<\/jats:styled-content>), 3\u00a0months (<jats:styled-content style=\"fixed-case\">De<\/jats:styled-content>), or 17\u00a0months (<jats:styled-content style=\"fixed-case\">La<\/jats:styled-content>) after tooth extraction. Second\u2010stage surgery was performed after 3\u00a0months of submerged healing; metal\u2010ceramic crowns were cemented after one additional month. Standardized periapical radiographs were taken 1\u00a0week after implant placement (<jats:styled-content style=\"fixed-case\">T<jats:sub>P<\/jats:sub><\/jats:styled-content>), 1\u00a0week (<jats:styled-content style=\"fixed-case\">T<jats:sub>C<\/jats:sub><\/jats:styled-content>) and 1\u20131.5\u00a0year (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content><jats:sub>1<\/jats:sub>) after crown delivery, and 10\u00a0years after implant placement (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content><jats:sub>10<\/jats:sub>). Pocket depth (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) and bleeding on probing were registered during controls (<jats:styled-content style=\"fixed-case\">T<jats:sub>C<\/jats:sub><\/jats:styled-content> \u2013 <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content><jats:sub>10<\/jats:sub>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two <jats:styled-content style=\"fixed-case\">Ea<\/jats:styled-content> and one <jats:styled-content style=\"fixed-case\">De<\/jats:styled-content> implants failed to osseointegrate. Seven patients (4 <jats:styled-content style=\"fixed-case\">Ea<\/jats:styled-content>, 1 <jats:styled-content style=\"fixed-case\">De<\/jats:styled-content>, and 2 <jats:styled-content style=\"fixed-case\">La<\/jats:styled-content>) were not available at <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content><jats:sub>10<\/jats:sub>. No significant differences were found among groups regarding implant survival or radiographic peri\u2010implant marginal bone levels (Ea: 1.15\u00a0\u00b1\u00a00.77; <jats:styled-content style=\"fixed-case\">De<\/jats:styled-content>: 1.53\u00a0\u00b1\u00a01.06; <jats:styled-content style=\"fixed-case\">La<\/jats:styled-content>: 1.42\u00a0\u00b1\u00a01.07) at T<jats:sub>10<\/jats:sub>. Similarly, no differences were observed among groups in the number of implants with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> \u22655\u00a0mm (Ea: 29%; <jats:styled-content style=\"fixed-case\">De<\/jats:styled-content>: 35%; <jats:styled-content style=\"fixed-case\">La<\/jats:styled-content>: 44%) or the average depth of the sites with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> \u22655\u00a0mm (Ea: 5.4\u00a0\u00b1\u00a00.7; De: 6.1\u00a0\u00b1\u00a01.4; La: 5.4\u00a0\u00b1\u00a00.5) at <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content><jats:sub>10<\/jats:sub>. Peri\u2010implant mucositis was found in 70% of the cases; peri\u2010implantitis was diagnosed only in two implants (1 <jats:styled-content style=\"fixed-case\">De<\/jats:styled-content>, 1 <jats:styled-content style=\"fixed-case\">La<\/jats:styled-content>) corresponding to 4.3%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Single\u2010tooth implants placed early or delayed after tooth extraction show high survival rates and limited peri\u2010implant marginal bone resorption or biological complications, similar to what is observed with implants placed according to the conventional (late) protocol.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12273","type":"journal-article","created":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T13:26:56Z","timestamp":1401974816000},"page":"1359-1365","source":"Crossref","is-referenced-by-count":34,"title":["Early, delayed, or late single implant placement: 10\u2010year results from a randomized controlled clinical trial"],"prefix":"10.1111","volume":"25","author":[{"given":"Lars","family":"Schropp","sequence":"first","affiliation":[{"name":"Prosthetic Dentistry Department of Dentistry Aarhus University Aarhus Denmark"},{"name":"Oral Radiology Department of Dentistry Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Wenzel","sequence":"additional","affiliation":[{"name":"Oral Radiology Department of Dentistry Aarhus University Aarhus Denmark"},{"name":"Radiology Department of Odontology University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Stavropoulos","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Community Dentistry Malm\u00f6 University Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9785(81)80077-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12017"},{"key":"e_1_2_6_4_1","first-page":"365","volume-title":"Proceedings of the 1st European Workshop on Periodontology","author":"Albrektsson T.","year":"1994"},{"key":"e_1_2_6_5_1","first-page":"11","article-title":"The long\u2010term efficacy of currently used dental implants: a review and proposed criteria of success","volume":"1","author":"Albrektsson T.","year":"1986","journal-title":"The International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00726.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2006.01317.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2006.01315.x"},{"key":"e_1_2_6_9_1","first-page":"376","article-title":"Guided tissue regeneration for implants placed into extraction sockets and for implant dehiscences: surgical techniques and case report","volume":"10","author":"Becker W.","year":"1990","journal-title":"The International Journal of Periodontics & Restorative Dentistry"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.29.s3.12.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00565.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2005.01105.x"},{"key":"e_1_2_6_13_1","first-page":"11","volume-title":"Tissue\u2010Integrated Prostheses. 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