{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:02:19Z","timestamp":1791576139743,"version":"4.3.4"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,12,31]],"date-time":"2013-12-31T00:00:00Z","timestamp":1388448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of the present systematic review and meta\u2010analysis was to assess the role of periodontal disease as a risk factor for implant loss, peri\u2010implantitis and implant\u2010bone loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      Six electronic database and a manual search resulted in 7391 unique publications; after selection only 16 studies were included in systematic review. Dichotomous data were expressed as risk ratio (\n                      <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\n                      ) and 95% confidence interval (\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ), while continuous data were expressed as standardized mean difference (\n                      <jats:styled-content style=\"fixed-case\">SMD<\/jats:styled-content>\n                      ). Due to the expected inter\u2010study heterogeneity, a random effect model was used for both type of data. The pooled effect was considered significant for a\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Meta\u2010analysis revealed that an higher and significant risk for implant loss was present in patients affected by\n                      <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                      (\n                      <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\n                      : 1.69, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 1.31\u20132.17,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &lt;\u00a00.0001). A higher and significant\n                      <jats:styled-content style=\"fixed-case\">IBL<\/jats:styled-content>\n                      was present in patients with periodontal disease, when compared with patients periodontally healthy (\n                      <jats:styled-content style=\"fixed-case\">SMD<\/jats:styled-content>\n                      : 0.38, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 0.18\u20130.58,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a00.0002). Patients periodontally compromised showed an increased risk of\n                      <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>\n                      , when compared with patients without periodontitis (\n                      <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\n                      : 2.17, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 1.51\u20133.12,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &lt;\u00a00.0001) No evidence of significant heterogeneity was detected for the three outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Strong evidence suggests that periodontitis is a risk factor for implant loss; moderate evidence revealed that periodontitis is a risk factor for peri\u2010implantitis and that patients with periodontitis have higher implant\u2010bone loss.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.12319","type":"journal-article","created":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T09:26:26Z","timestamp":1401960386000},"source":"Crossref","is-referenced-by-count":114,"title":["Periodontitis, implant loss and peri\u2010implantitis. 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