{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:59:59Z","timestamp":1792645199138,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,20]],"date-time":"2014-01-20T00:00:00Z","timestamp":1390176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bisphosphonates are a widely used class of drugs that prevent bone loss. Several side effects related to bisphosphonate therapy have been reported, including osteonecrosis of the jaws associated with invasive dental procedures and implants placement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the influence of intravenous nitrogen\u2010containing <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>s in combination with or without dexamethasone on osseointegration of titanium implants placed in an animal model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010seven male Wistar rats were divided into three groups: group 1 was treated solely with zoledronic acid, group 2 was treated with zoledronic acid and dexamethasone, and group 3 did only receive saline solution injections. Two endosseous implants were placed in each tibia, and three animals from each group were sacrificed at postoperative times of seven, 14, and 28\u00a0days. Non\u2010decalcified sections were observed with light microscopy for histological and histomorphometrical analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histomorphometrical analysis using the animals and the implants as unit of measurement revealed no statistically significant difference regarding bone\u2010implant contact and bone density among the three groups. Histological observation revealed that zoledronic acid\u2010treated animals in combination with or without dexamethasone showed expressive less bone remodeling activity at 14 and 28\u00a0days after implants placement, compared with control specimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The studied bisphosphonate regimens did not interfere with the osseointegration of the implants, cortical, or medular bone deposition, but a possible lack of bone remodeling of the original cortical bone may affect long\u2010term osseointegration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12335","type":"journal-article","created":{"date-parts":[[2014,1,20]],"date-time":"2014-01-20T11:31:52Z","timestamp":1390217512000},"source":"Crossref","is-referenced-by-count":16,"title":["The effects of zoledronic acid and dexamethasone on osseointegration of endosseous implants: histological and histomorphometrical evaluation in rats"],"prefix":"10.1111","volume":"26","author":[{"given":"Marcio A.","family":"de Oliveira","sequence":"first","affiliation":[{"name":"Department of Stomatology School of Dentistry University of Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise A.","family":"Asahi","sequence":"additional","affiliation":[{"name":"Department of Stomatology School of Dentistry University of Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celey A. 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