{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:52:30Z","timestamp":1787737950251,"version":"build-2784847793"},"reference-count":55,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T00:00:00Z","timestamp":1396224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Conselleria de Salut i Consum from the Balearic Government and by Mateu Orfila Foundation"},{"name":"Ministry of Science and Innovation of Spain"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Although the clinical success of Bio\u2010Oss<jats:sup>\u00ae<\/jats:sup> and BoneCeramic<jats:sup>\u00ae<\/jats:sup> has been corroborated by histologic and histomorphometric findings, the biological events that occur during healing after maxillary sinus floor elevation (<jats:styled-content style=\"fixed-case\">MSFE<\/jats:styled-content>) are unknown. Here, we evaluated biopsies of grafted bone with a mixture of autologous bone and Bio\u2010Oss<jats:sup>\u00ae<\/jats:sup> or BoneCeramic<jats:sup>\u00ae<\/jats:sup> after two different healing time periods to understand the molecular process underlying bone formation after <jats:styled-content style=\"fixed-case\">MSFE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Seven patients, following a bilateral split\u2010mouth design model and needing a <jats:styled-content style=\"fixed-case\">MSFE<\/jats:styled-content> to allow implant placement, were recruited for this study. Right or left sinuses were grafted with autologous maxillary bone combined either with Bio\u2010Oss<jats:sup>\u00ae<\/jats:sup> or BoneCeramic<jats:sup>\u00ae<\/jats:sup>, respectively. Twenty biopsies were taken at the time of implant insertion after 4\u20135\u00a0months or 6\u20138\u00a0months of <jats:styled-content style=\"fixed-case\">MSFE<\/jats:styled-content>, and analyzed by micro\u2010computed tomography (micro<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) and gene\u2010expression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Micro<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> analysis revealed no differences in the morphometric parameters or <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> either after 4\u20135\u00a0months or 6\u20138\u00a0months of <jats:styled-content style=\"fixed-case\">MSFE<\/jats:styled-content> between Bio\u2010Oss<jats:sup>\u00ae<\/jats:sup> and BoneCeramic<jats:sup>\u00ae<\/jats:sup>. At molecular level, a higher expression of bone forming gene Runx2 was observed after 4\u20135\u00a0months of <jats:styled-content style=\"fixed-case\">MSFE<\/jats:styled-content> in the Bio\u2010Oss<jats:sup>\u00ae<\/jats:sup> compared with the BoneCeramic<jats:sup>\u00ae<\/jats:sup> group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate that differences found at the molecular level between Bio\u2010Oss<jats:sup>\u00ae<\/jats:sup> and BoneCeramic<jats:sup>\u00ae<\/jats:sup> are not translated to important differences in the 3D microstructure and <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> of the grafted bone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12380","type":"journal-article","created":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T04:52:57Z","timestamp":1396241577000},"page":"727-735","source":"Crossref","is-referenced-by-count":25,"title":["Gene expression and morphometric parameters of human bone biopsies after maxillary sinus floor elevation with autologous bone combined with Bio\u2010Oss<sup>\u00ae<\/sup> or BoneCeramic<sup>\u00ae<\/sup>"],"prefix":"10.1111","volume":"26","author":[{"given":"Jorge","family":"Caubet","sequence":"first","affiliation":[{"name":"Bone regeneration and Oral and Maxillofacial Surgery Unit (GBCOM) Palma de Mallorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana M.","family":"Ramis","sequence":"additional","affiliation":[{"name":"Department of Fundamental Biology and Health Sciences Research Institute on Health Sciences (IUNICS) Universitat de les Illes Balears Palma de Mallorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikel","family":"Ramos\u2010Murguialday","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Son Espases Hospital Palma de Mallorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel 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